Molecular studies of CGRP and the CGRP family of peptides in the central nervous system.

Autor: Hendrikse ER; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand., Bower RL; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand., Hay DL; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand.; 2 Centre for Brain Research, University of Auckland, Auckland, New Zealand., Walker CS; 1 School of Biological Sciences, University of Auckland, Auckland, New Zealand.
Jazyk: angličtina
Zdroj: Cephalalgia : an international journal of headache [Cephalalgia] 2019 Mar; Vol. 39 (3), pp. 403-419. Date of Electronic Publication: 2018 Mar 22.
DOI: 10.1177/0333102418765787
Abstrakt: Background: Calcitonin gene-related peptide is an important target for migraine and other painful neurovascular conditions. Understanding the normal biological functions of calcitonin gene-related peptide is critical to understand the mechanisms of calcitonin gene-related peptide-blocking therapies as well as engineering improvements to these medications. Calcitonin gene-related peptide is closely related to other peptides in the calcitonin gene-related peptide family of peptides, including amylin. Relatedness in peptide sequence and in receptor biology makes it difficult to tease apart the contributions that each peptide and receptor makes to physiological processes and to disorders.
Summary: The focus of this review is the expression of calcitonin gene-related peptide, related peptides and their receptors in the central nervous system. Calcitonin gene-related peptide is expressed throughout the nervous system, whereas amylin and adrenomedullin have only limited expression at discrete sites in the brain. The components of two receptors that respond to calcitonin gene-related peptide, the calcitonin gene-related peptide receptor (calcitonin receptor-like receptor with receptor activity-modifying protein 1) and the AMY 1 receptor (calcitonin receptor with receptor activity-modifying protein 1), are expressed throughout the nervous system. Understanding expression of the peptides and their receptors lays the foundation for more deeply understanding their physiology, pathophysiology and therapeutic use.
Databáze: MEDLINE
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