Ru(ii)-Catalyzed spirocyclization of aryl N-sulfonyl ketimines with aryl isocyanates through an aromatic C-H bond activation.
| Autor: | K NR; Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad - 500 007, India. basireddy@iict.res.in and Academy of Scientific and Innovative Research (AcSIR), New Delhi - 110025, India., U S; Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad - 500 007, India. basireddy@iict.res.in., B S; Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology, Hyderabad - 500 007, India., B V SR; Centre for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Hyderabad - 500 007, India. basireddy@iict.res.in. |
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| Jazyk: | angličtina |
| Zdroj: | Organic & biomolecular chemistry [Org Biomol Chem] 2018 Apr 04; Vol. 16 (14), pp. 2522-2526. |
| DOI: | 10.1039/C7OB03198J |
| Abstrakt: | A novel one-pot strategy has been developed for the construction of spiro-isoindolinone-benzosultams through a Ru(ii)-catalyzed sequential C-C and C-N bond formation. This method is highly atom-economical and compatible with a wide range of substituents. This is the first report on the spirocyclization of 3-aryl N-sulfonyl ketimines with aryl isocyanates to produce highly rigid and pharmaceutically relevant spirocycles through a C-H bond activation. |
| Databáze: | MEDLINE |
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