In Vitro Assessment of Total Phenolic and Flavonoid Contents, Antioxidant and Photoprotective Activities of Crude Methanolic Extract of Aerial Parts of Capnophyllum peregrinum (L.) Lange (Apiaceae) Growing in Algeria.

Autor:	Lefahal M; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. mlefahal@gmail.com., Zaabat N; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. z_nabila2002@yahoo.fr., Ayad R; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. radia.ayad@yahoo.fr., Makhloufi EH; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. makhloufi_el_hani@yahoo.fr., Djarri L; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. djarri62@gmail.com., Benahmed M; Department of Chemistry, Faculty of Science, University of Tebessa, Tebessa 12000, Algeria. Riad43200@yahoo.fr., Laouer H; Laboratory of Natural Biological Resources Valorization, Faculty of Sciences, University of Setif, Setif 19000, Algeria. hocine_laouer@yahoo.fr., Nieto G; Department of Food Technology, Nutrition and Food Science, Faculty of veterinary Sciences, University of Murcia, Campus de Espinardo, Espinardo, 30100 Murcia, Spain. gnieto@um.es., Akkal S; Valorization of Natural Resources, Bioactive Molecules and Biological Analysis Unit, Department of Chemistry, University of Mentouri Constantine, Constantine 25000, Algeria. salah4dz@yahoo.fr.
Jazyk:	angličtina
Zdroj:	Medicines (Basel, Switzerland) [Medicines (Basel)] 2018 Mar 22; Vol. 5 (2). Date of Electronic Publication: 2018 Mar 22.
DOI:	10.3390/medicines5020026
Abstrakt:	Background: Capnophyllum peregrinum (L.) Lange (Apiaceae) is the unique taxon of capnophyllum genus in Algerian flora. It has never been investigated in regards to its total phenolic and flavonoid contents and antioxidant and photoprotective activities. Methods: C. peregrinum aerial parts extracted with absolute methanol. The total flavonoid and phenolic contents of the extract were evaluated to determine their correlation with the antioxidant and photoprotective activities of the extract. Results: The methanolic extract demonstrated a significant amount of phenolics and flavonoids (74.06 ± 1.23 mg GAE/g, 44.09 ± 2.13 mg QE/g, respectively) and exhibited good antioxidant activity in different systems, especially in 1,1-Diphenyl-2-picrylhydrazyl (DPPH), reducing power and total antioxidant capacity assays. Furthermore the extract showed high photoprotective activity with the sun protection factor (SPF) value = 35.21 ± 0.18. Conclusions: The results of the present study show, that the methanolic extract could be used as a natural sunscreen in pharmaceutics or cosmetic formulations and as a valuable source of natural antioxidants. Competing Interests: The authors report no financial or nonfinancial conflict of interest. The authors alone are responsible for the content and writing of the paper.
Databáze:	MEDLINE
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