Self-nanoemulsifying drug-delivery systems improve oral absorption and antischistosomal activity of epiisopiloturine.

Autor:	de Lima LI; Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil., Py-Daniel KR; Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil., Guimarães MA; Phytobios Pesquisa Desenvolvimento e Inovação LTDA, Parnaíba, Piauí, Brazil.; Núcleo de Pesquisa em Biodiversidade e Biotecnologia, BIOTEC, Universidade Federal do Piauí, Parnaíba, Piauí, Brazil.; Programa de pós-graduação em Biotecnologia, RENORBIO, Ponto Focal Universidade Federal do Piauí, Teresina, Piauí, Brasil., Muehlmann LA; Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil.; Faculty of Ceilandia, University of Brasilia, Brasilia 72220-900, Brazil., Mafud AC; Instituto de Física de São Carlos, Departamento de Física e Ciência Interdisciplinar, Universidade de São Paulo, São Carlos - SP, 13566-590, Brazil.; Department Medical Parasitology & Infection Biology, Swiss Tropical & Public Health Institute, Basel, 4051, Switzerland., Mascarenhas YP; Instituto de Física de São Carlos, Departamento de Física e Ciência Interdisciplinar, Universidade de São Paulo, São Carlos - SP, 13566-590, Brazil., Moraes J; Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Praça Tereza Cristina, 88, 07023-070, Guarulhos, SP, Brazil., de Souza de Almeida Leite JR; Area Morphology, Faculty of Medicine, University of Brasília (UnB), University Campus Darcy Ribeiro, Asa Norte, 70910-900, Brasília-DF, Brazil., Jiang CS; School of Biological Science & Technology, University of Jinan, Jinan 250022, PR China., Azevedo RB; Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil., Figueiró Longo JP; Genetics & Morphology Department, Institute of Biological Science, University of Brasilia, Brasília, Brazil.
Jazyk:	angličtina
Zdroj:	Nanomedicine (London, England) [Nanomedicine (Lond)] 2018 Apr 01; Vol. 13 (7), pp. 689-702. Date of Electronic Publication: 2018 Mar 22.
DOI:	10.2217/nnm-2017-0308
Abstrakt:	Aim: To develop a self-nanoemulsifying drug-delivery system (SNEDDS) able to improve oral absorption of epiisopiloturine (EPI), and test the antischistosomal activity in a mice model. Results: SNEDDS had a nanoscopic size and was able to enhance EPI bioavailability after oral administration, and SNEDDS-EPI (40 mg.kg -1 ) improved the in vivo antischistosomal activity of EPI, demonstrating that SNEDDS was able to improve the pharmacokinetics of EPI, and to maintain the pharmacodynamic activity against Schistosoma mansoni in vivo. Conclusion: Taken together, these results indicate that SNEDDS-EPI is efficient in reducing worm burden in comparison to treatment with the free version of EPI. [Formula: see text].
Databáze:	MEDLINE
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