| Autor: |
Arnoni MV; Hospital Infantil Darcy Vargas, São Paulo, SP, Brazil., Paula CR; Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil., Auler ME; Departamento de Farmácia, Universidade Estadual do Centro-Oeste do Paraná (UNICENTRO), Guarapuava, PR, Brazil., Simões CCN; Hospital Infantil Darcy Vargas, São Paulo, SP, Brazil., Nakano S; Hospital Infantil Darcy Vargas, São Paulo, SP, Brazil., Szeszs MW; Secção de Micologia, Instituto Adolfo Lutz (IAL), São Paulo, SP, Brazil., Melhem MSC; Secção de Micologia, Instituto Adolfo Lutz (IAL), São Paulo, SP, Brazil., Pereira VBR; Núcleo de Ciências Biomédicas, Instituto Adolfo Lutz (IAL), CLR II, Bauru, SP, Brazil., Garces HG; Departamento de Microbiologia e Imunologia, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Bagagli E; Departamento de Microbiologia e Imunologia, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil., Silva EG; Faculdade de Odontologia, Universidade de São Paulo (USP), São Paulo, SP, Brazil., de Macêdo MF; Hospital Infantil Darcy Vargas, São Paulo, SP, Brazil., Ruiz LDS; Núcleo de Ciências Biomédicas, Instituto Adolfo Lutz (IAL), CLR II, Bauru, SP, Brazil. lu_ruiz74@hotmail.com.; Instituto Adolfo Lutz - Rua Rubens Arruda, s/n, quadra 06, Centro, Bauru, SP, CEP 17015-110, Brazil. lu_ruiz74@hotmail.com. |
| Abstrakt: |
Fusarium species have emerged as responsible for a broad spectrum of infections, including superficial, locally invasive and disseminated ones, especially in the hospital environment. Since there are few reports of invasive and disseminated fusariosis in children, the aim of this study was to report four cases of nosocomial infection caused by this microorganism in children with cancer hospitalized in a public children's hospital located in Brazil. Two of these patients were female and two were male. All patients presented febrile neutropenia, while three patients had acute lymphocytic leukemia and one patient had Wilms' tumor as underlying disease. In two cases, fungi were isolated from blood and identified as Fusarium oxysporum species complex after phenotypic and genotypic studies, while in two other cases fungi were isolated from skin biopsies and identified as Fusarium solani species complex. One patient died 12 days after the onset of cutaneous lesions. All isolates, after susceptibility testing, presented high levels of minimum inhibitory concentration for itraconazole, voriconazole and amphotericin B. Considering the emergence of filamentous fungi as etiologic agents of nosocomial infections, health professionals should be aware of the problems these infections, especially fungal ones, may cause to debilitated patients. |
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