Ancylostoma ceylanicum , novel etiological agent for traveler's diarrhea-report of four Japanese patients who returned from Southeast Asia and Papua New Guinea.

Autor: Yoshikawa M; 1Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, 634-8521 Japan., Ouji Y; 1Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, 634-8521 Japan., Hirai N; 1Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, 634-8521 Japan.; 2Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan., Nakamura-Uchiyama F; 1Department of Pathogen, Infection and Immunity, Nara Medical University, Shijo-cho, Kashihara, Nara, 634-8521 Japan.; 2Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan., Yamada M; 3Department of Infectious Diseases, Kyoto Prefectural University of Medicine, Kyoto, 612-8369 Japan., Arizono N; 3Department of Infectious Diseases, Kyoto Prefectural University of Medicine, Kyoto, 612-8369 Japan., Akamatsu N; Department of Gastroenterology, Omihachiman Community Medical Center, Omihachiman, Japan., Yoh T; Department of Gastroenterology, Omihachiman Community Medical Center, Omihachiman, Japan., Kaya D; Department of Gastroenterology, Nara Prefectural General Medical Center, Nara, Japan., Nakatani T; Department of Gastroenterology, Nara Prefectural General Medical Center, Nara, Japan., Kikuchi E; Department of Gastroenterology, Nara Prefectural General Medical Center, Nara, Japan., Katanami Y; 6Department of Infectious Diseases, Nara City Hospital, Nara, Japan., Satoh K; 6Department of Infectious Diseases, Nara City Hospital, Nara, Japan., Maki R; Department of Infectious Diseases, Osaka General Medical Center, Osaka, Japan., Miyazato Y; Department of Infectious Diseases, Osaka General Medical Center, Osaka, Japan., Oba Y; Department of Infectious Diseases, Osaka General Medical Center, Osaka, Japan., Kasahara K; 2Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan., Mikasa K; 2Center for Infectious Diseases, Nara Medical University, Shijo-cho, Kashihara, Nara, Japan.
Jazyk: angličtina
Zdroj: Tropical medicine and health [Trop Med Health] 2018 Mar 13; Vol. 46, pp. 6. Date of Electronic Publication: 2018 Mar 13 (Print Publication: 2018).
DOI: 10.1186/s41182-018-0087-8
Abstrakt: Background: Countries in the Southeast Asia region have a high prevalence of soil-transmitted helminth, such as roundworm, whipworm, and hookworms [ Ancylostoma duodenale , Necator americanus , Ancylostoma ceylanicum ]. Recent molecular-based surveys have revealed that A . ceylanicum , a zoonotic hookworm, is likely the second most prevalent hookworm species infecting humans in that part of the world, while others have noted that this infection is an emerging public health risk not only for indigenous people but also for visitors from other countries.
Case Presentation: We recently encountered four cases of A . ceylanicum infection in Japanese individuals who returned from Southeast Asia and Papua New Guinea. Case 1 was a 25-year-old male who stayed in a rainforest in Malaysia for 4 weeks, where he developed abdominal pain and diarrhea in the third week. Eleven adult worms (five males, six females) were expelled after treatment with pyrantel pamoate and identified as A . ceylanicum based on morphological characteristics and DNA sequences of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene. Case 2 was a 26-year-old male who spent 2 years as an overseas cooperation volunteer for agriculture in Papua New Guinea. He did not note any symptoms at that time, though eggs were detected in feces samples at a medical check-up examination after returning. Although collection of adult worms was unsuccessful, DNA analysis of the eggs for cox1 and the ribosomal internal transcribed spacer (ITS)-1 and ITS-2 genes demonstrated that they were A . ceylanicum. Case 3 was a 47-year-old male who spent 1 month in a rural village in Lao People's Democratic Republic and began suffering from watery diarrhea from the third week. A total of nine adult worms (three males, six females) were collected by endoscopic procedures and following treatment with pyrantel pamoate. Morphological examination and molecular analyses of the cox1 gene showed that they were A . ceylanicum. Case 4 was a 27-year-old male who participated in group travel to India for 5 days. Three weeks after returning, he developed abdominal pain and diarrhea. Hookworm eggs were found in feces samples and developed into larvae in culture, which were identified as A . ceylanicum based on molecular analysis of the cox1 gene . Eosinophilia was observed in all of the cases prior to treatment.
Conclusions: A . ceylanicum should be recognized as an important etiologic pathogen of hookworm diseases in travelers to countries in the Southeast Asia and West Pacific Ocean regions.
Competing Interests: This is not a research project involving people or animals, only a case report. Therefore, the requirement in our local setting is to get consent for publication.Written informed consent was obtained from the patient for publication of this report and any accompanying images.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Databáze: MEDLINE
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