Clinicopathological and 123 I-FP-CIT SPECT correlations in patients with dementia.

Autor: Jung Y; Department of Neurology Mayo Clinic Rochester Minnesota., Jordan LG 3rd; Department of Radiology Mayo Clinic Rochester Minnesota., Lowe VJ; Department of Radiology Mayo Clinic Rochester Minnesota., Kantarci K; Department of Radiology Mayo Clinic Rochester Minnesota., Parisi JE; Department of Neurology Mayo Clinic Rochester Minnesota.; Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota., Dickson DW; Department of Neuroscience Mayo Clinic Jacksonville Florida., Murray ME; Department of Neuroscience Mayo Clinic Jacksonville Florida., Reichard RR; Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota., Ferman TJ; Department of Psychiatry and Psychology Mayo Clinic Jacksonville Florida., Jones DT; Department of Neurology Mayo Clinic Rochester Minnesota., Graff-Radford J; Department of Neurology Mayo Clinic Rochester Minnesota., Savica R; Department of Neurology Mayo Clinic Rochester Minnesota., Machulda MM; Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota., Fields JA; Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota., Allen LA; Department of Neurology Mayo Clinic Rochester Minnesota., Drubach DA; Department of Neurology Mayo Clinic Rochester Minnesota., St Louis EK; Department of Neurology Mayo Clinic Rochester Minnesota.; Center for Sleep Medicine Mayo Clinic Rochester Minnesota., Silber MH; Department of Neurology Mayo Clinic Rochester Minnesota.; Center for Sleep Medicine Mayo Clinic Rochester Minnesota., Jack CR Jr; Department of Radiology Mayo Clinic Rochester Minnesota., Knopman DS; Department of Neurology Mayo Clinic Rochester Minnesota., Petersen RC; Department of Neurology Mayo Clinic Rochester Minnesota., Boeve BF; Department of Neurology Mayo Clinic Rochester Minnesota.; Center for Sleep Medicine Mayo Clinic Rochester Minnesota.
Jazyk: angličtina
Zdroj: Annals of clinical and translational neurology [Ann Clin Transl Neurol] 2018 Jan 24; Vol. 5 (3), pp. 376-381. Date of Electronic Publication: 2018 Jan 24 (Print Publication: 2018).
DOI: 10.1002/acn3.521
Abstrakt: The relationship between clinicopathologic diagnosis and 123 I-FP-CIT SPECT in 18 patients with dementia (12 with Lewy body disease) from one center in the United States was assessed. The sensitivity and specificity of abnormal 123 I-FP-CIT SPECT with reduced striatal uptake on visual inspection for predicting Lewy body disease were 91.7% and 83.3%, respectively. The mean calculated putamen to occipital ratio (mPOR) based on regions of interest was significantly reduced in Lewy body disease compared to non-Lewy body disease cases ( P = 0.002). In this study, abnormal 123 I-FP-CIT SPECT was strongly associated with underlying Lewy body disease pathology, supporting the utility of 123 I-FP-CIT SPECT in the clinical diagnosis of dementia with Lewy bodies.
Databáze: MEDLINE
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