Activity of TP-6076 against carbapenem-resistant Acinetobacter baumannii isolates collected from inpatients in Greek hospitals.

Autor: Falagas ME; Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Department of Medicine, Henry Dunant Hospital Center, Athens, Greece; Department of Medicine, Tufts University School of Medicine, Boston, MA, USA. Electronic address: m.falagas@aibs.gr., Skalidis T; Central Laboratories, IASO Group Hospitals, Athens, Greece., Vardakas KZ; Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Department of Medicine, Henry Dunant Hospital Center, Athens, Greece., Voulgaris GL; Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece; Laboratory of Pharmacokinetics and Toxicology, Department of Pharmacy, 401 General Military Hospital, Athens, Greece., Papanikolaou G; Bioprepare Microbiology, Athens, Greece., Legakis N; Central Laboratories, IASO Group Hospitals, Athens, Greece.
Jazyk: angličtina
Zdroj: International journal of antimicrobial agents [Int J Antimicrob Agents] 2018 Aug; Vol. 52 (2), pp. 269-271. Date of Electronic Publication: 2018 Mar 17.
DOI: 10.1016/j.ijantimicag.2018.03.009
Abstrakt: TP-6076 is a synthetic fluorocycline antibiotic that inhibits bacterial protein synthesis. In this study, carbapenem-resistant Acinetobacter baumannii clinical isolates from 13 Greek hospitals were tested for susceptibility to TP-6076 and comparator antibiotics. Broth microdilution plates were used to determine minimum inhibitory concentrations (MICs). A total of 121 non-duplicate A. baumannii isolates were tested. The MIC 50 and MIC 90 values of TP-6076 were 0.03 mg/L and 0.06 mg/L, respectively. Tigecycline was the second most active antibiotic (MIC 90 , 2 mg/L), followed by minocycline (MIC 90 , 8 mg/L). TP-6076 exhibited MIC 90 values that were one dilution lower against tigecycline- and minocycline-susceptible isolates than against resistant isolates. There was no difference in the MIC 90 value for colistin-susceptible or -resistant isolates. In conclusion, TP-6076 exhibited greater antimicrobial activity in vitro against carbapenem-resistant A. baumannii than comparator antibiotics.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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