Role of proton balance in formation of self-assembled chitosan nanoparticles.

Autor: Dey A; Department of Chemical Engineering, Institute of Chemical Technology, Matunga, Mumbai 400019, India., Kamat A; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400019, India., Nayak S; Department of Chemical Engineering, Institute of Chemical Technology, Matunga, Mumbai 400019, India., Danino D; Department of Biotechnology & Food Engineering, Technion - Israel Institute of Technology, Hafia 3200003, Israel., Kesselman E; Department of Biotechnology & Food Engineering, Technion - Israel Institute of Technology, Hafia 3200003, Israel., Dandekar P; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address: pd.jain@ictmumbai.edu.in., Jain R; Department of Chemical Engineering, Institute of Chemical Technology, Matunga, Mumbai 400019, India. Electronic address: rd.jain@ictmumbai.edu.in.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2018 Jun 01; Vol. 166, pp. 127-134. Date of Electronic Publication: 2018 Mar 14.
DOI: 10.1016/j.colsurfb.2018.03.017
Abstrakt: Researchers have explored the ability of chitosan to form nanoparticles, to suit varying applications, ranging from wound-healing to gene delivery. Ionic gelation is a widely used method for formulating chitosan nanoparticles, where self-assembly plays a crucial role. This self-assembly is initially promoted by hydrophilic-hydrophobic parity amongst individual chitosan residues, along with electrostatic and Van der Waals interactions with the cross-linker. However, until now the intrinsic ability of chitosan to self-assemble is not widely studied; hence, we investigate the self-assembly of chitosan, based on proton balance between its protonated and deprotonated residues, to promote facile nanoparticle synthesis. This is one of the first reports that highlights subtle but critical influence of proton balance in the chitosan polymer on the formation of chitosan nanoparticles.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: