Deltamethrin-induced nuclear erythrocyte alteration and damage to the gills and liver of Colossoma macropomum.

Autor: Cunha FDS; Tiradentes University, Av. Murilo Dantas, 300, Farolândia, Aracaju, SE, 49032-490, Brazil., Sousa NDC; Federal University of Pará, Alameda Leandro Ribeiro, s/n, Aldeia, Bragança, PA, 68600-000, Brazil., Santos RFB; Federal University of Pernambuco, Enzymology Lab, Department of Biochemistry, Av. Prof. Moraes Rego, s/n, Cidade Universitária, Recife, PE, 50670-420, Brazil., Meneses JO; Tiradentes University, Av. Murilo Dantas, 300, Farolândia, Aracaju, SE, 49032-490, Brazil., do Couto MVS; Federal University of Pará, Alameda Leandro Ribeiro, s/n, Aldeia, Bragança, PA, 68600-000, Brazil., de Almeida FTC; Bahia Regional College, Av. Marechal Cândido Rondon, s/n Capucho, Aracaju, SE, 49050-680, Brazil., de Sena Filho JG; EMBRAPA-Tabuleiros Costeiros, Av. Beira Mar, 3250, Jardins, Aracaju, SE, 49025-040, Brazil., Carneiro PCF; EMBRAPA-Tabuleiros Costeiros, Av. Beira Mar, 3250, Jardins, Aracaju, SE, 49025-040, Brazil., Maria AN; EMBRAPA-Tabuleiros Costeiros, Av. Beira Mar, 3250, Jardins, Aracaju, SE, 49025-040, Brazil., Fujimoto RY; EMBRAPA-Tabuleiros Costeiros, Av. Beira Mar, 3250, Jardins, Aracaju, SE, 49025-040, Brazil. ryfujim@hotmail.com.
Jazyk: angličtina
Zdroj: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2018 May; Vol. 25 (15), pp. 15102-15110. Date of Electronic Publication: 2018 Mar 20.
DOI: 10.1007/s11356-018-1622-1
Abstrakt: Deltamethrin is one of the most commonly used pyrethroids in the world, and it has a high toxic potential, mainly on aquatic organism. Thus, the purpose of this study was to evaluate LC 50 values of deltamethrin on tambaqui (Colossoma macropomum) fingerlings and to investigate genotoxic effects and histopathological responses. Fish were exposed to different concentrations of deltamethrin (0, 6.16 × 10 -3 ; 6.44 × 10 -2 ; 1.34 × 10 -1 , and 1.93 × 10 -1  mg L -1 ) for 96 h. In addition, a genotoxicity analysis was carried out on peripheral blood erythrocytes and histopathological changes were classified by the severity degree of damage and organ functioning. The 96 h LC 50 value for tambaqui was estimated at 5.56 × 10 -2  mg L -1 using a static test system. Nuclear abnormalities in exposed fish included micronuclei, blebbed, notched, 8-shaped, and binucleated nuclei forms. Deltamethrin significantly induced a notched nucleus compared to other abnormalities. A histopathological examination showed hepatic lesions and gill damage. Deltamethrin was found to be highly toxic; it induced genotoxicity and caused liver and gill inflammation in tambaqui.
Databáze: MEDLINE
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