Arterial stiffness evaluated by pulse wave velocity is not predictive of the improvement in hypertension after adrenal surgery for primary aldosteronism: A multicentre study from the French European Society of Hypertension Excellence Centres.

Autor: Bouhanick B; Department of Therapeutics and Hypertension, Rangueil University Hospital, 31059 Toulouse, France; UMR 1027 INSERM Toulouse 3 University, 31000 Toulouse, France. Electronic address: duly-bouhanick.b@chu-toulouse.fr., Amar J; Department of Therapeutics and Hypertension, Rangueil University Hospital, 31059 Toulouse, France; INSERM 1048 Toulouse 3 University, 31432 Toulouse, France., Amar L; Hypertension Unit, hôpital Européen-Georges-Pompidou, université Paris Descartes, Assistance publique-Hôpitaux de Paris, 75908 Paris, France., Gosse P; Department of Cardiology and Hypertension, Bordeaux University Hospital, 33076 Bordeaux, France., Girerd X; Unité de prévention cardiovasculaire, University Hospital Pitié-Salpêtrière, 75651 Paris, France., Reznik Y; Department of Endocrinology, Côte de Nacre Regional Hospital Center, University of Caen, 14033 Caen, France., Mounier-Vehier C; Service de médecine vasculaire et HTA, University Hospital Lille, 59037 Lille, France., Baguet JP; Department of Cardiology, Mutualist hospital Group, 38100 Grenoble, France., Boutouyrie P; Inserm, U970, Pharmacology Unit, hôpital Européen Georges-Pompidou, AP-HP, 75908 Paris, France; Cardiovascular Research Center PARCC, University Paris Descartes, Sorbonne Paris Cité, 75015 Paris, France., Lepage B; UMR 1027 INSERM Toulouse 3 University, 31000 Toulouse, France; Department of Epidemiology, Toulouse University Hospital, 31000 Toulouse, France., Lantelme P; Cardiology Department, hospices civils de Lyon, hôpital de la Croix-Rousse, 69004 Lyon, France., Chamontin B; Department of Therapeutics and Hypertension, Rangueil University Hospital, 31059 Toulouse, France.
Jazyk: angličtina
Zdroj: Archives of cardiovascular diseases [Arch Cardiovasc Dis] 2018 Oct; Vol. 111 (10), pp. 564-572. Date of Electronic Publication: 2018 Mar 16.
DOI: 10.1016/j.acvd.2018.01.004
Abstrakt: Background: Predictive factors associated with normal blood pressure (BP) after unilateral adrenalectomy for primary aldosteronism (PA) are not clearly identified.
Aims: To evaluate the predictive value of arterial stiffness before surgery on BP after surgery.
Methods: During 2009-2013, 96 patients with PA due to unilateral adrenal adenoma who underwent surgery were enrolled in a multicentre open-label, prospective study. Aortic pulse wave velocity (PWV) was assessed before surgery. Patients underwent ambulatory blood pressure monitoring (ABPM) before surgery and 6 and 12months after surgery. Twenty-four h SBP/DBP values were compared in subjects with PWVResults: BP and PWV were available for 82 patients (mean age 49±12years). Mean 24-hour systolic/diastolic BP (SBP/DBP) values decreased from 144±15/91±9 before surgery to 131±15/84±11mmHg 6months after surgery. At 6months, mean 24-hour SBP did not differ significantly between high versus low PWV groups (SBP-0.8mmHg, 95% confidence interval-6.9 to 5.2, P=0.79). A total of 42.3% of women versus 20.0% of men had 24-hour SBP/DBP<130/80mmHg at 6months (P=0.07) and 57.9% vs. 23.8% at 12months (P=0.03). Higher SBP/DBP was recorded for men versus women after 6months (P=0.01/0.001) and 1year (P=0.04/0.05).
Conclusion: Preoperative arterial stiffness does not predict a beneficial effect of adrenalectomy on BP values.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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