| Autor: |
Lutgring JD, Zhu W, de Man TJB, Avillan JJ, Anderson KF, Lonsway DR, Rowe LA, Batra D, Rasheed JK, Limbago BM |
| Jazyk: |
angličtina |
| Zdroj: |
Emerging infectious diseases [Emerg Infect Dis] 2018 Apr; Vol. 24 (4), pp. 700-709. |
| DOI: |
10.3201/eid2404.171377 |
| Abstrakt: |
Oxacillinase (OXA)-48-like carbapenemases remain relatively uncommon in the United States. We performed phenotypic and genotypic characterization of 30 Enterobacteriaceae producing OXA-48-like carbapenemases that were recovered from patients during 2010-2014. Isolates were collected from 12 states and not associated with outbreaks, although we could not exclude limited local transmission. The alleles β-lactamase OXA-181 (bla OXA-181 ) (43%), bla OXA-232 (33%), and bla OXA-48 (23%) were found. All isolates were resistant to ertapenem and showed positive results for the ertapenem and meropenem modified Hodge test and the modified carbapenem inactivation method; 73% showed a positive result for the Carba Nordmann-Poirel test. Whole-genome sequencing identified extended-spectrum β-lactamase genes in 93% of isolates. In all bla OXA-232 isolates, the gene was on a ColKP3 plasmid. A total of 12 of 13 isolates harboring bla OXA-181 contained the insertion sequence ΔISEcp1. In all isolates with bla OXA-48 , the gene was located on a TN1999 transposon; these isolates also carried IncL/M plasmids. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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