| Autor: |
Sultanov R; Federal Research and Clinical Center of Physical Chemical Medicine of the Federal Medical and Biological Agency of the Russian Federation, Russia., Lebedeva O; Federal Research and Clinical Center of Physical Chemical Medicine of the Federal Medical and Biological Agency of the Russian Federation, Russia.; Vavilov Institute of General Genetics of the Russian Academy of Sciences, Russia., Arapidi G; Federal Research and Clinical Center of Physical Chemical Medicine of the Federal Medical and Biological Agency of the Russian Federation, Russia., Lagarkova M; Federal Research and Clinical Center of Physical Chemical Medicine of the Federal Medical and Biological Agency of the Russian Federation, Russia.; Vavilov Institute of General Genetics of the Russian Academy of Sciences, Russia., Kiselev S; Vavilov Institute of General Genetics of the Russian Academy of Sciences, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Data in brief [Data Brief] 2018 Jan 31; Vol. 17, pp. 662-666. Date of Electronic Publication: 2018 Jan 31 (Print Publication: 2018). |
| DOI: |
10.1016/j.dib.2018.01.061 |
| Abstrakt: |
The genetic reprogramming technology allows generation of induced pluripotent stem cells (iPSCs) from somatic cells (Takahashi and Yamanaka, 2006) [1]. iPSCs have the ability to self-renew, and to differentiate into any type of somatic cells, and are considered as a promising tool for drug development, disease modeling, and regenerative medicine. The reprogramming factors (oct4, sox2, klf4, c-myc) can be delivered to the cell nucleus either by vectors integrating into the genome (lentiviruses, retroviruses) or by non-integrative methods (e.g., plasmids, Sendai virus, synthetic mRNAs and recombinant proteins). To evaluate the contribution of the reprogramming process isogenic system should be utilized (Shutova et al., 2016) [2]. Isogenic iPSC lines, obtained in different ways can serve the ideal system to investigate DNA methylation changes. The data presented in this article report methylation profiles for iPSC lines derived from fibroblasts of a healthy donor and PARK8-associated Parkinson's disease patient via integrating (lentiviral transfection) and non-integrating (Sendai virus infection) reprogramming using an Illumina 450K Methylation BeadChip platform. The data on DNA methylation of neurons differentiated from iPSC lines are also provided here. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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