Contemporary strategies for dissecting the neuronal basis of neurodevelopmental disorders.

Autor: Seo DO; Departmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States., Motard LE; Departmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States., Bruchas MR; Departmentof Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, United States; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, United States; Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO 63110, United States; Washington University Pain Center, Washington University School of Medicine, St. Louis, MO 63110, United States. Electronic address: bruchasm@wustl.edu.
Jazyk: angličtina
Zdroj: Neurobiology of learning and memory [Neurobiol Learn Mem] 2019 Nov; Vol. 165, pp. 106835. Date of Electronic Publication: 2018 Mar 14.
DOI: 10.1016/j.nlm.2018.03.015
Abstrakt: Great efforts in clinical and basic research have shown progress in understanding the neurobiological mechanisms of neurodevelopmental disorders, such as autism, schizophrenia, and attention-deficit hyperactive disorders. Literature on this field have suggested that these disorders are affected by the complex interaction of genetic, biological, psychosocial and environmental risk factors. However, this complexity of interplaying risk factors during neurodevelopment has prevented a complete understanding of the causes of those neuropsychiatric symptoms. Recently, with advances in modern high-resolution neuroscience methods, the neural circuitry analysis approach has provided new solutions for understanding the causal relationship between dysfunction of a neural circuit and behavioral alteration in neurodevelopmental disorders. In this review we will discuss recent progress in developing novel optogenetic and chemogenetic strategies to investigate neurodevelopmental disorders.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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