Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo.

Autor: Sevost'yanov MA; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Nasakina EO; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Baikin AS; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Sergienko KV; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Konushkin SV; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Kaplan MA; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Seregin AV; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia.; Bauman Moscow State Technical University, Moscow, Russia., Leonov AV; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia.; Bauman Moscow State Technical University, Moscow, Russia., Kozlov VA; Bauman Moscow State Technical University, Moscow, Russia.; A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia., Shkirin AV; A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia.; National Research Nuclear University MEPhI, Moscow, Russia., Bunkin NF; Bauman Moscow State Technical University, Moscow, Russia.; A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia., Kolmakov AG; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Simakov SV; Baikov Institute of Metallurgy and Materials Science, Russian Academy of Sciences, Moscow, Russia., Gudkov SV; A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia. S_makariy@rambler.ru.; Depatment of Biophysics, Lobachevsky State University of Nizhni Novgorod, Nizhni Novgorod, Russia. S_makariy@rambler.ru.; Moscow Regional Research and Clinical Institute (MONIKI), Moscow, Russia. S_makariy@rambler.ru.
Jazyk: angličtina
Zdroj: Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2018 Mar 15; Vol. 29 (3), pp. 33. Date of Electronic Publication: 2018 Mar 15.
DOI: 10.1007/s10856-018-6039-3
Abstrakt: A technology for obtaining materials from nanostructured nitinol with titanium- or tantalum-enriched surface layers was developed. Surface layers enriched with titanium or tantalum were shown to provide a decrease in the formation of reactive oxygen species and long-lived protein radicals in comparison to untreated nitinol. It was determined that human peripheral vessel myofibroblasts and human bone marrow mesenchymal stromal cells grown on nitinol bases coated with titanium or tantalum-enriched surface layers exhibit a nearly two times higher mitotic index. Response to implantation of pure nitinol, as well as nano-structure nitinol with titanium or tantalum-enriched surface layers, was expressed though formation of a mature uniform fibrous capsule peripherally to the fragment. The thickness of this capsule in the group of animals subjected to implantation of pure nitinol was 1.5 and 3.0-fold greater than that of the capsule in the groups implanted with nitinol fragments with titanium- or tantalum-enriched layers. No signs of calcinosis in the tissues surrounding implants with coatings were observed. The nature and structure of the formed capsules testify bioinertia of the implanted samples. It was shown that the morphology and composition of the surface of metal samples does not alter following biological tests. The obtained results indicate that nano-structure nitinol with titanium or tantalum enriched surface layers is a biocompatible material potentially suitable for medical applications.
Databáze: MEDLINE
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