Tissue-Specific Immunoregulation: A Call for Better Understanding of the "Immunostat" in the Context of Cancer.

Autor:	Pao W; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland. william.pao@roche.com., Ooi CH; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Birzele F; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Ruefli-Brasse A; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Cannarile MA; Roche Innovation Center Munich, F. Hoffmann-La Roche AG, Munich, Germany., Reis B; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Scharf SH; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Schubert DA; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Hatje K; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Pelletier N; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Spleiss O; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland., Reed JC; Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.
Jazyk:	angličtina
Zdroj:	Cancer discovery [Cancer Discov] 2018 Apr; Vol. 8 (4), pp. 395-402. Date of Electronic Publication: 2018 Mar 15.
DOI:	10.1158/2159-8290.CD-17-1320
Abstrakt:	Checkpoint inhibitor therapy has been a breakthrough in cancer research, but only some patients with cancer derive substantial benefit. Although mechanisms underlying sensitivity and resistance to checkpoint inhibitors are being elucidated, the importance of organ-specific regulation of immunity is currently underappreciated. Here, we call for a greater understanding of tissue-specific immunoregulation, namely, "tissue-specific immunostats," to make advances in treatments for cancer. A better understanding of how individual organs at baseline regulate the immune system could enable an improved precision medicine approach to cancer immunotherapy. Cancer Discov; 8(4); 395-402. ©2018 AACR . (©2018 American Association for Cancer Research.)
Databáze:	MEDLINE
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