Aquatic environmental risk assessment of chitosan/silver, copper and carbon nanotube nanocomposites as antimicrobial agents.

Autor: Abu-Elala NM; Department of Fish Diseases and Management, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., AbuBakr HO; Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Khattab MS; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt., Mohamed SH; Department of Immunology, Animal Health Research Institute, Dokki, Giza, Egypt., El-Hady MA; Department of Fish Diseases, Animal Health Research Institute, Dokki, Giza, Egypt., Ghandour RA; Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt., Morsi RE; Analysis and Evaluation Department, Egyptian Petroleum Research Institute, Nasr City, PO Box 11727, Cairo, Egypt; EPRI-Nanotechnology Center, Egyptian Petroleum Research Institute, Nasr City, PO Box 11727, Cairo, Egypt. Electronic address: raniaelsayed@yahoo.com.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2018 Jul 01; Vol. 113, pp. 1105-1115. Date of Electronic Publication: 2018 Mar 12.
DOI: 10.1016/j.ijbiomac.2018.03.047
Abstrakt: Despite the potential antimicrobial and water purification benefits of chitosan-based nanocomposites, there are growing concerns regarding the hazards of leached nanoparticles (NPs) to the in-contact circumference. The antibacterial performance of the nanocomposites of chitosan with silver and copper NPs and carbon nanotubes was assessed with an emphasis on their impact on fish health. The minimal inhibitory concentrations of each preparation and the growth curves of Aeromonas hydrophila exposed to different nanocomposites were measured. Five groups of Oreochromis niloticus were exposed to chitosan nanocomposites for three weeks. A combination of a low concentration of the NPs in the chitosan matrix improved their antimicrobial properties. However, aqueous exposure to these materials still had hazardous effects on fish health. Experimental groups of O. niloticus exposed to these nanocomposites exhibited oxidative stress, tissue DNA fragmentation and higher expression of pro-inflammatory and immune-related genes such as TNF-α and IL1β. Various pathological tissue alterations were observed in gills, liver, spleen and intestine. Exposure to some of the prepared nanocomposites led to significant DNA damage in hepatic cells with a marked increase in the apoptotic index.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: