| Autor: |
Truong AD; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea.; National Institute of Veterinary Research, 86 Truong Chinh, Dong Da, Hanoi, Vietnam., Hoang CT; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea., Hong Y; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea., Lee J; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea., Lee K; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea., Lillehoj HS; Animal Biosciences and Biotechnology Laboratory, Agricultural Research Services, United States Department of Agriculture, Beltsville, MD 20705, USA., Hong YH; Department of Animal Science and Technology, Chung-Ang University, Anseong 17546, Republic of Korea. |
| Abstrakt: |
The data herein is related to the research article entitled "Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex" [1] where we demonstrated that the chicken interleukin (IL)-23α, IL-12p40, and IL-23 complex regulates Th1, Th17, and Treg cytokine production through heterodimer receptors as well as a homodimer receptor consisting of IL-12Rβ1 and IL-23R, and activates the JAK/STAT signaling pathways. Here, we evaluated the effects of the recombinant chicken IL-23α, IL-12p40, and IL-23 complex protein on cell proliferation and nitric oxide (NO) production in chicken macrophage (HD11) and CU91 T cell lines. In addition, the expression of IL-6, IL-17A, and interferon-γ mRNA were upregulated in vivo and in vitro . Moreover, treatment with the chicken IL-23α, IL-12p40, and IL-23 complex activated phosphorylation of tyrosine and serine residues in JAK2, STAT1, TYK2, and SOCS1 in chicken cell lines. |
