How best to capture the respiratory consequences of prematurity?

Autor:	Ciuffini F; Respiratory Research, Murdoch Children's Research Institute, Melbourne, Australia francesca.ciuffini@unimi.it.; NICU, Dept of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.; Respiratory Medicine, Royal Children's Hospital, Parkville, Australia., Robertson CF; Respiratory Research, Murdoch Children's Research Institute, Melbourne, Australia.; Respiratory Medicine, Royal Children's Hospital, Parkville, Australia.; Dept of Paediatrics, University of Melbourne, Melbourne, Australia., Tingay DG; Dept of Paediatrics, University of Melbourne, Melbourne, Australia.; Neonatal Research, Murdoch Children's Research Institute, Melbourne, Australia.; Neonatology, Royal Children's Hospital, Melbourne, Australia.
Jazyk:	angličtina
Zdroj:	European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2018 Mar 14; Vol. 27 (147). Date of Electronic Publication: 2018 Mar 14 (Print Publication: 2018).
DOI:	10.1183/16000617.0108-2017
Abstrakt:	Chronic respiratory morbidity is a common complication of premature birth, generally defined by the presence of bronchopulmonary dysplasia, both clinically and in trials of respiratory therapies. However, recent data have highlighted that bronchopulmonary dysplasia does not correlate with chronic respiratory morbidity in older children born preterm. Longitudinally evaluating pulmonary morbidity from early life through to childhood provides a more rational method of defining the continuum of chronic respiratory morbidity of prematurity, and offers new insights into the efficacy of neonatal respiratory interventions. The changing nature of preterm lung disease suggests that a multimodal approach using dynamic lung function assessment will be needed to assess the efficacy of a neonatal respiratory therapy and predict the long-term respiratory consequences of premature birth. Our aim is to review the literature regarding the long-term respiratory outcomes of neonatal respiratory strategies, the difficulties of assessing dynamic lung function in infants, and potential new solutions. Competing Interests: Conflict of interest: None declared. (Copyright ©ERS 2018.)
Databáze:	MEDLINE
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