Running for extinction? Aerobic exercise as an augmentation of exposure therapy in panic disorder with agoraphobia.

Autor: Bischoff S; Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany. Electronic address: sophie.bischoff@charite.de., Wieder G; Technische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Chemnitzer Str. 46, 01187, Dresden, Germany., Einsle F; Technische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Chemnitzer Str. 46, 01187, Dresden, Germany., Petzold MB; Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany., Janßen C; Department of Psychology, Humboldt Universität Berlin, Unter den Linden 6, 10099, Berlin, Germany., Mumm JLM; Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany., Wittchen HU; Technische Universität Dresden, Institute of Clinical Psychology and Psychotherapy, Chemnitzer Str. 46, 01187, Dresden, Germany; Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität, Nußbaumstraße 7, 80336, Munich, Germany., Fydrich T; Department of Psychology, Humboldt Universität Berlin, Unter den Linden 6, 10099, Berlin, Germany., Plag J; Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany., Ströhle A; Charité- Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Psychiatry and Psychotherapy, Campus Mitte, Charitéplatz 1, 10117, Berlin, Germany.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2018 Jun; Vol. 101, pp. 34-41. Date of Electronic Publication: 2018 Mar 05.
DOI: 10.1016/j.jpsychires.2018.03.001
Abstrakt: Exposure-based Cognitive Behavioral Therapy (eb-CBT) represents the most evidence-based psychotherapeutic approach in anxiety disorders. However, its efficacy may be limited by a delay in onset of action and a substantial number of patients does not respond sufficiently to treatment. In this context, aerobic exercise was found to be effective in reducing clinical anxiety as well as to improve (elements of) disorder-specific CBT in some mental disorders. We therefore investigated the effect of aerobic exercise supplementary to an eb-CBT in panic disorder and agoraphobia (PD/AG). 77 patients with PD/AG performed a 30 min treadmill task with moderate or low intensity (70% or 30% of the maximal oxygen uptake [VO 2max ]) prior to five exposure sessions within a standardized seven-week CBT. At baseline, after completing the treatment period (post) and six month after post (follow-up), several measures of (un)specific psychopathology (Hamilton Anxiety Rating Scale [Ham-A], Mobility Inventory [MI], Panic and Agoraphobia Scale [PAS], Agoraphobic Cognitions Questionnaire [ACQ], Body Sensations Questionnaire [BSQ]) were established to assess for clinical changes. All patients experienced a significant improvement of symptoms from baseline to post (for all measures p < .001) but repeated-measures analyses of variance found a trend towards a significant time × group interaction in the Ham-A in favor for the moderate intense exercise group (f[1, 74] = 4.15, p = .045, α=.025). This trend, however, disappeared at follow-up since the low-intense exercise group further improved significantly in Ham-A after post. Our findings therefore might point to an accelerating effect of moderate-intense exercise within an exposure-based CBT for AG/PD.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: