Prevalence of sustained remission in rheumatoid arthritis: impact of criteria sets and disease duration, a Nationwide Study in Sweden.

Autor:	Einarsson JT; Lund University, Department of Clinical Sciences, Section of Rheumatology, Lund, Skåne University Hospital, Lund, Sweden., Willim M; Lund University, Department of Clinical Sciences, Section of Rheumatology, Lund, Skåne University Hospital, Lund, Sweden., Ernestam S; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.; Centre of Rheumatology, Stockholm County Council, Stockholm, Sweden., Saxne T; Lund University, Department of Clinical Sciences, Section of Rheumatology, Lund, Skåne University Hospital, Lund, Sweden., Geborek P; Lund University, Department of Clinical Sciences, Section of Rheumatology, Lund, Skåne University Hospital, Lund, Sweden., Kapetanovic MC; Lund University, Department of Clinical Sciences, Section of Rheumatology, Lund, Skåne University Hospital, Lund, Sweden.
Jazyk:	angličtina
Zdroj:	Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2019 Feb 01; Vol. 58 (2), pp. 227-236.
DOI:	10.1093/rheumatology/key054
Abstrakt:	Objectives: The aims of this national study in Sweden of patients with RA were to: examine the prevalence of sustained remission (SR), that is, remission lasting for at least 6 months; compare the prevalence of SR in patients with early RA and established RA; study the timing of onset of and time spent in SR; and study possible predictors of SR. Methods: Adult patients with RA included in the Swedish Rheumatology Quality registry were studied. The registry was searched for patients fulfilling remission criteria: DAS28-ESR, Clinical Disease Activity Index (CDAI), Simplified Disease Activity Index (SDAI) and ACR/EULAR remission for at least 6 months. Early RA was defined as symptom duration ⩽6 months at inclusion in the Swedish Rheumatology Quality. Results: Of 29 084 patients, 12 193 (41.9%) reached DAS28 SR at some time point during follow-up compared with 6445 (22.2%), 6199 (21.3%) and 5087 (17.5%) for CDAI, SDAI and ACR/EULAR SR, respectively. SR was more common in early RA (P < 0.001). The median time from symptom onset to SR was 1.9, 2.4, 2.4 and 2.5 years according to DAS28, CDAI, SDAI and ACR/EULAR criteria, respectively. Lower age, male sex and milder disease characteristics were associated with SR. Conclusion: The majority of patients in this nationwide study never reached SR. Patients with early RA are more likely to reach SR than patients with established RA.
Databáze:	MEDLINE
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