Scedosporium and Lomentospora: an updated overview of underrated opportunists.

Autor: Ramirez-Garcia A; Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain., Pellon A; Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain., Rementeria A; Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain., Buldain I; Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain., Barreto-Bergter E; Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil., Rollin-Pinheiro R; Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil., de Meirelles JV; Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil., Xisto MIDS; Instituto de Microbiologia, UFRJ, Rio de Janeiro, RJ, Brazil., Ranque S; Laboratoire de Parasitologie-Mycologie, AP-HM / CHU Timone, Marseille, France., Havlicek V; Institute of Microbiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic., Vandeputte P; Laboratoire de Parasitologie-Mycologie, CHU, Angers, France.; Host-Pathogen Interaction Study Group (EA 3142), UNIV Angers, UNIV Brest, Angers, France., Govic YL; Laboratoire de Parasitologie-Mycologie, CHU, Angers, France.; Host-Pathogen Interaction Study Group (EA 3142), UNIV Angers, UNIV Brest, Angers, France., Bouchara JP; Laboratoire de Parasitologie-Mycologie, CHU, Angers, France.; Host-Pathogen Interaction Study Group (EA 3142), UNIV Angers, UNIV Brest, Angers, France., Giraud S; Host-Pathogen Interaction Study Group (EA 3142), UNIV Angers, UNIV Brest, Angers, France., Chen S; Centre for Infectious Diseases and Microbiology Laboratory Services, ICPMR, Westmead Hospital, The University of Sydney, New South Wales, Australia., Rainer J; Institute of Microbiology, Leopold-Franzens University Innsbruck, Austria., Alastruey-Izquierdo A; Mycology Reference Laboratory, National Centre for Microbiology. Instituto de Salud Carlos III. Majadahonda, Madrid, Spain., Martin-Gomez MT; Microbiology Department. Hospital Universitari Vall d'Hebron, Barcelona, Spain., López-Soria LM; Microbiology Department. Hospital Universitario Cruces, Barakaldo, Spain., Peman J; Microbiology Department, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Schwarz C; Cystic Fibrosis Centre Berlin/Charité-Universitätsmedizin Berlin, Germany., Bernhardt A; Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Berlin, Germany., Tintelnot K; Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Berlin, Germany., Capilla J; Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, Reus, Spain., Martin-Vicente A; Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, Reus, Spain.; Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN USA., Cano-Lira J; Mycology Unit, Medical School and IISPV, Universitat Rovira i Virgili, Reus, Spain., Nagl M; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria., Lackner M; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria., Irinyi L; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School, Sydney Medical School - Westmead Hospital, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead Institute for Medical Research, Sydney, New South Wales, Australia., Meyer W; Molecular Mycology Research Laboratory, Centre for Infectious Diseases and Microbiology, Westmead Clinical School, Sydney Medical School - Westmead Hospital, Marie Bashir Institute for Infectious Diseases and Biosecurity, The University of Sydney, Westmead Institute for Medical Research, Sydney, New South Wales, Australia., de Hoog S; Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands., Hernando FL; Fungal and Bacterial Biomics Research Group, Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Leioa, Spain.
Jazyk: angličtina
Zdroj: Medical mycology [Med Mycol] 2018 Apr 01; Vol. 56 (suppl_1), pp. 102-125.
DOI: 10.1093/mmy/myx113
Abstrakt: Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
Databáze: MEDLINE