The Physical Activity and Alzheimer's Disease (PAAD) Study: Cognitive outcomes.

Autor:	Etnier JL; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Karper WB; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Labban JD; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Piepmeier AT; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Shih CH; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Dudley WN; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Henrich VC; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC., Wideman L; Department of Kinesiology, University of North Carolina at Greensboro, Coleman, Greensboro NC.
Jazyk:	angličtina
Zdroj:	Annals of behavioral medicine : a publication of the Society of Behavioral Medicine [Ann Behav Med] 2018 Feb 05; Vol. 52 (2), pp. 175-185.
DOI:	10.1093/abm/kax035
Abstrakt:	Background: Alzheimer's disease is a progressive disease that degrades cognitive functioning and ultimately results in death. Currently, there is no cure for Alzheimer's disease and, hence, the identification of preventative strategies is important. Physical activity (PA) is a behavioral intervention that holds promise with respect to delaying the onset of Alzheimer's disease. Purpose: The purpose of this study was to explore the differential cognitive benefits achieved in response to PA as a function of a person's genetic risk for AD. Methods: Older cognitively normal adults (50-65 years) with a family history of AD (FHxAD) participated in an 8-month PA program. Cognitive performance was measured at baseline, pretest, midtest, and posttest and changes over time were assessed as a function of apolipoprotein E (APOE) status (carriers: 1-2 copies of the ɛ4 allele; noncarriers: 0 copies of the ɛ4 allele). Results: Improvements in memory were associated with PA participation irrespective of APOE ɛ4 carrier status. Conclusions: Future experimental studies are needed to confirm that PA causes improvements to cognitive performance in older cognitively normal adults with a FHxAD and that these improvements are equivalent for cognitively normal APOE ɛ4 carriers and noncarriers.
Databáze:	MEDLINE
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