Analysis of Vestibular Labyrinthine Geometry and Variation in the Human Temporal Bone.

Autor:	Johnson Chacko L; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Schmidbauer DT; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Biotechnology & Food Engineering, Management Center Innsbruck, Innsbruck, Austria., Handschuh S; VetImaging, VetCore Facility for Research, University of Veterinary Medicine, Vienna, Austria., Reka A; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Fritscher KD; Institute of Biomedical Image Analysis, UMIT, Hall in Tirol, Austria., Raudaschl P; Institute of Biomedical Image Analysis, UMIT, Hall in Tirol, Austria., Saba R; MED-El GmbH, Innsbruck, Austria., Handler M; Institute of Electrical and Biomedical Engineering, UMIT, Hall in Tirol, Austria., Schier PP; Institute of Electrical and Biomedical Engineering, UMIT, Hall in Tirol, Austria., Baumgarten D; Institute of Electrical and Biomedical Engineering, UMIT, Hall in Tirol, Austria.; Institute of Biomedical Engineering and Informatics, Technische Universität Ilmenau, Ilmenau, Germany., Fischer N; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria., Pechriggl EJ; Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria., Brenner E; Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria., Hoermann R; Division of Clinical and Functional Anatomy, Department of Anatomy, Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria., Glueckert R; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria.; University Clinics Innsbruck, Tirol Kliniken, Innsbruck, Austria., Schrott-Fischer A; Department of Otolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2018 Feb 26; Vol. 12, pp. 107. Date of Electronic Publication: 2018 Feb 26 (Print Publication: 2018).
DOI:	10.3389/fnins.2018.00107
Abstrakt:	Stable posture and body movement in humans is dictated by the precise functioning of the ampulla organs in the semi-circular canals. Statistical analysis of the interrelationship between bony and membranous compartments within the semi-circular canals is dependent on the visualization of soft tissue structures. Thirty-one human inner ears were prepared, post-fixed with osmium tetroxide and decalcified for soft tissue contrast enhancement. High resolution X-ray microtomography images at 15 μm voxel-size were manually segmented. This data served as templates for centerline generation and cross-sectional area extraction. Our estimates demonstrate the variability of individual specimens from averaged centerlines of both bony and membranous labyrinth. Centerline lengths and cross-sectional areas along these lines were identified from segmented data. Using centerlines weighted by the inverse squares of the cross-sectional areas, plane angles could be quantified. The fit planes indicate that the bony labyrinth resembles a Cartesian coordinate system more closely than the membranous labyrinth. A widening in the membranous labyrinth of the lateral semi-circular canal was observed in some of the specimens. Likewise, the cross-sectional areas in the perilymphatic spaces of the lateral canal differed from the other canals. For the first time we could precisely describe the geometry of the human membranous labyrinth based on a large sample size. Awareness of the variations in the canal geometry of the membranous and bony labyrinth would be a helpful reference in designing electrodes for future vestibular prosthesis and simulating fluid dynamics more precisely.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu