Association of the SOD2 Polymorphism (Val16Ala) and SOD Activity with Vaso-occlusive Crisis and Acute Splenic Sequestration in Children with Sickle Cell Anemia.

Autor: Farias ICC; Biological Science Institute, University of Pernambuco Pernambuco, Brazil., Mendonça-Belmont TF; Biological Science Institute, University of Pernambuco Pernambuco, Brazil.; Post-Graduation Program in Biotechnology (RENORBIO), Federal Rural University of Pernambuco, Brazil., da Silva AS; Biological Science Institute, University of Pernambuco Pernambuco, Brazil., do Ó KP; Biological Science Institute, University of Pernambuco Pernambuco, Brazil., Ferreira F; Federal University of Pernambuco, Brazil., Medeiros FS; Biological Science Institute, University of Pernambuco Pernambuco, Brazil., da Silva Vasconcelos LR; Research Center Aggeu Magalhães (CPqAM), Oswaldo Cruz Foundation (Fiocruz), Brazil., Bezerra MAC; Federal University of Pernambuco, Brazil.; Hematology and Hemotherapy Foundation of Pernambuco (HEMOPE), Brazil., da Silva Araújo A; Hematology and Hemotherapy Foundation of Pernambuco (HEMOPE), Brazil., de Moura PMMF; Biological Science Institute, University of Pernambuco Pernambuco, Brazil., Hatzlhofer BLD; Federal University of Pernambuco, Brazil., Dos Anjos ACM; Hematology and Hemotherapy Foundation of Pernambuco (HEMOPE), Brazil., de Mendonça Cavalcanti MDS; Biological Science Institute, University of Pernambuco Pernambuco, Brazil.; Post-Graduation Program in Biotechnology (RENORBIO), Federal Rural University of Pernambuco, Brazil.
Jazyk: angličtina
Zdroj: Mediterranean journal of hematology and infectious diseases [Mediterr J Hematol Infect Dis] 2018 Feb 21; Vol. 10 (1), pp. e2018012. Date of Electronic Publication: 2018 Feb 21 (Print Publication: 2018).
DOI: 10.4084/MJHID.2018.012
Abstrakt: The SOD2 polymorphism Val16Ala T→C influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with the vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children with SCA aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC and CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be a susceptibility factor for the occurrence of VOC and ASS.
Competing Interests: Competing interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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