Genetics and Genomics of Social Behavior in a Chicken Model.

Autor:	Johnsson M; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden.; The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, EH25 9RG UK.; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 750 07 Uppsala, Sweden., Henriksen R; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden., Fogelholm J; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden., Höglund A; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden., Jensen P; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden., Wright D; AVIAN Behavioural Genomics and Physiology group, IFM Biology, Linköping University, 58183, Sweden domwright@gmail.com.
Jazyk:	angličtina
Zdroj:	Genetics [Genetics] 2018 May; Vol. 209 (1), pp. 209-221. Date of Electronic Publication: 2018 Mar 12.
DOI:	10.1534/genetics.118.300810
Abstrakt:	The identification of genes affecting sociality can give insights into the maintenance and development of sociality and personality. In this study, we used the combination of an advanced intercross between wild and domestic chickens with a combined QTL and eQTL genetical genomics approach to identify genes for social reinstatement, a social and anxiety-related behavior. A total of 24 social reinstatement QTL were identified and overlaid with over 600 eQTL obtained from the same birds using hypothalamic tissue. Correlations between overlapping QTL and eQTL indicated five strong candidate genes, with the gene TTRAP being strongly significantly correlated with multiple aspects of social reinstatement behavior, as well as possessing a highly significant eQTL. (Copyright © 2018 by the Genetics Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu