Evolutionarily conserved anterior expansion of the central nervous system promoted by a common PcG-Hox program.

Autor:	Yaghmaeian Salmani B; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Monedero Cobeta I; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Rakar J; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Bauer S; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Curt JR; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Starkenberg A; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden., Thor S; Department of Clinical and Experimental Medicine, Linkoping University, SE-58185 Linkoping, Sweden stefan.thor@liu.se.
Jazyk:	angličtina
Zdroj:	Development (Cambridge, England) [Development] 2018 Apr 05; Vol. 145 (7). Date of Electronic Publication: 2018 Apr 05.
DOI:	10.1242/dev.160747
Abstrakt:	A conserved feature of the central nervous system (CNS) is the prominent expansion of anterior regions (brain) compared with posterior (nerve cord). The cellular and regulatory processes driving anterior CNS expansion are not well understood in any bilaterian species. Here, we address this expansion in Drosophila and mouse. We find that, compared with the nerve cord, the brain displays extended progenitor proliferation, more elaborate daughter cell proliferation and more rapid cell cycle speed in both Drosophila and mouse. These features contribute to anterior CNS expansion in both species. With respect to genetic control, enhanced brain proliferation is severely reduced by ectopic Hox gene expression, by either Hox misexpression or by loss of Polycomb group (PcG) function. Strikingly, in PcG mutants, early CNS proliferation appears to be unaffected, whereas subsequent brain proliferation is severely reduced. Hence, a conserved PcG-Hox program promotes the anterior expansion of the CNS. The profound differences in proliferation and in the underlying genetic mechanisms between brain and nerve cord lend support to the emerging concept of separate evolutionary origins of these two CNS regions. Competing Interests: Competing interestsThe authors declare no competing or financial interests. (© 2018. Published by The Company of Biologists Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu