Early and long term anamnestic response to HBV booster dose among fully vaccinated Egyptian children during infancy.

Autor: Salama II; Community Medicine Research Department, National Research Centre, Egypt. Electronic address: salamaiman@yahoo.com., Sami SM; Child Health Department, National Research Centre, Egypt., Said ZN; Microbiology and Immunology Department, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt., Salama SI; Community Medicine Research Department, National Research Centre, Egypt., Rabah TM; Community Medicine Research Department, National Research Centre, Egypt., Abdel-Latif GA; Community Medicine Research Department, National Research Centre, Egypt., Elmosalami DM; Community Medicine Research Department, National Research Centre, Egypt., Saleh RM; Community Medicine Research Department, National Research Centre, Egypt., Abdel Mohsin AM; Community Medicine Research Department, National Research Centre, Egypt., Metwally AM; Community Medicine Research Department, National Research Centre, Egypt., Hassanin AI; Child Health Department, National Research Centre, Egypt., Emam HM; Dermatology and Venereology Department, National Research Centre, Egypt., Hemida SA; Community Medicine Research Department, National Research Centre, Egypt., Elserougy SM; Environmental and Occupational Medicine Department, National Research Centre, Egypt., Shaaban FA; Child Health Department, National Research Centre, Egypt., Fouad WA; Community Medicine Research Department, National Research Centre, Egypt., Mohsen A; Community Medicine Research Department, National Research Centre, Egypt., El-Sayed MH; Pediatrics Department, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2018 Apr 05; Vol. 36 (15), pp. 2005-2011. Date of Electronic Publication: 2018 Mar 09.
DOI: 10.1016/j.vaccine.2018.02.103
Abstrakt: Objective: To evaluate early and long term anamnestic response to a booster dose of HBV vaccine among non-seroprotected children.
Subjects and Method: A national community based project was carried out on 3600 children aged 9 months to 16 years, fully vaccinated during infancy. They were recruited from 6 governorates representing Egypt. It revealed that 1535 children (42.8%) had non sero-protective anti-HBs (<10 IU/L) and were HBsAg or anti-HBc negative. A challenging dose of 10 μg of mono-valent Euvax HBV vaccine was given to 1121/1535 children. Quantitative assessment of anti-HBs was performed to detect early (2-4 weeks) and long term (one year) anamnestic responses.
Results: Early anamnestic response developed among 967/1070 children (90.3%).Children having detectable anti-HBs (1-9 IU/L) significantly developed early anamnestic response (90%) compared to 85% with undetectable anti-HBs (<1 IU/L), P < 0.001. Multiple logistic analysis revealed that undetectable anti-HBs, living in rural residence and children aged 15-16 years were the most significant predicting risk factors for the absence of early anamnestic response (<10 IU/L), with AOR 2.7, 2.7 & 4.7 respectively. After one year, long term anamnestic response was absent among 15% of children who previously showed early response. Poor early anamnestic response and undetectable pre-booster anti-HBs were the significant predicting risk factors for absent long term anamnestic response, with AOR 18.7 & 2.7 respectively.
Conclusion: Immunological memory for HBV vaccine outlasts the presence of anti- HBs and HBV vaccination program provides effective long term protection even in children showing waning or undetectable concentrations of anti-HBs. This signifies no need for a booster dose especially to healthy children.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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