Effect of infant feeding practices on iron status in a cohort study of Bolivian infants.

Autor: Burke RM; Department of Epidemiology, Rollins School of Public Health, Emory University, Claudia Nance Rollins Building, 1518 Clifton Rd. NE, Atlanta, GA, 30322, USA. Rachel.m.burke@gmail.com., Rebolledo PA; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Emory School of Medicine, Atlanta, GA, USA., Aceituno AM; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Revollo R; Servicio Departamental de Salud, La Paz, Bolivia., Iñiguez V; Instituto de Biotecnología y Microbiología, Universidad Mayor de San Andrés, La Paz, Bolivia., Klein M; Department of Epidemiology, Rollins School of Public Health, Emory University, Claudia Nance Rollins Building, 1518 Clifton Rd. NE, Atlanta, GA, 30322, USA., Drews-Botsch C; Department of Epidemiology, Rollins School of Public Health, Emory University, Claudia Nance Rollins Building, 1518 Clifton Rd. NE, Atlanta, GA, 30322, USA., Leon JS; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Suchdev PS; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Emory School of Medicine, Atlanta, GA, USA.; Nutrition Branch, Centers for Disease Control & Prevention, Atlanta, GA, USA.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2018 Mar 12; Vol. 18 (1), pp. 107. Date of Electronic Publication: 2018 Mar 12.
DOI: 10.1186/s12887-018-1066-2
Abstrakt: Background: Iron deficiency (ID) is the most common micronutrient deficiency worldwide, with potentially severe consequences on child neurodevelopment. Though exclusive breastfeeding (EBF) is recommended for 6 months, breast milk has low iron content. This study aimed to estimate the effect of the length of EBF on iron status at 6 - 8 months of age among a cohort of Bolivian infants.
Methods: Mother-infant pairs were recruited from 2 hospitals in El Alto, Bolivia, and followed from one through 6 - 8 months of age. Singleton infants > 34 weeks gestational age, iron-sufficient at baseline, and completing blood draws at 2 and 6 - 8 months of age were eligible for inclusion (N = 270). Ferritin was corrected for the effect of inflammation. ID was defined as inflammation-corrected ferritin < 12 μg/L, and anemia was defined as altitude-corrected hemoglobin < 11 g/dL; IDA was defined as ID plus anemia. The effect of length of EBF (infant received only breast milk with no other liquids or solids, categorized as < 4, 4 - 6, and > 6 months) was assessed for ID, IDA, and anemia (logistic regression) and ferritin (Fer) and hemoglobin (Hb, linear regression).
Results: Low iron status was common among infants at 6 - 8 months: 56% of infants were ID, 76% were anemic, and 46% had IDA. EBF of 4 months and above was significantly associated with ID as compared with EBF <  4 months (4 - 6 months: OR 2.0 [1.1 - 3.4]; > 6 months: 3.3 [1.0 - 12.3]), but not with IDA (4 - 6 months: OR 1.4 [0.8 - 2.4]; > 6 months: 2.2 [0.7 - 7.4]), or anemia (4 - 6 months: OR 1.4 [0.7 - 2.5]; > 6 months: 1.5 [0.7 - 7.2]). Fer and Hb concentrations were significantly lower with increasing months of EBF.
Conclusions: Results suggest a relationship between prolonged EBF and ID, but are not sufficient to support changes to current breastfeeding recommendations. More research is needed in diverse populations, including exploration of early interventions to address infant IDA.
Databáze: MEDLINE
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