Identification of immunohistochemical localization of irisin in the dwarf hamster (Phodopus roborovskii) tissues.

Autor: Gür FM; Department of Histology-Embryology, Faculty of Medicine, Ömer Halisdemir University, Niğde, Turkey., Timurkaan S; Department of Histology-Embryology, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Gençer Tarakçi B; Department of Histology-Embryology, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Yalçin MH; Department of Histology-Embryology, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Özkan ZE; Department of Anatomy, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Baygeldi SB; Department of Anatomy, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Yilmaz S; Department of Anatomy, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey., Eröksüz H; Department of Pathology, Faculty of Veterinary Medicine, Fırat University, Elazığ, Turkey.
Jazyk: angličtina
Zdroj: Anatomia, histologia, embryologia [Anat Histol Embryol] 2018 Apr; Vol. 47 (2), pp. 174-179.
DOI: 10.1111/ahe.12345
Abstrakt: Irisin is mainly secreted by heart and skeletal muscle cells. It is an exercise-induced protein that converts white adipose tissue to brown. Increased irisin expression was lead to weight loss and improved glucose tolerance. We investigated irisin immunoreactivity in various tissues of the dwarf hamsters (Phodopus roborovskii). Tissues were processed, embedded in paraffin, sectioned at 5 μm and stained immunohistochemically for irisin. In the retina, irisin was found almost all layers, except outer nuclear layer. Also, irisin immunoreactivity was observed in the skin, cornea, striated muscle, parotid gland, tongue, oesophagus, stomach and small intestine. The findings from this study support the notion that skeletal muscle is not the primary source of irisin.
(© 2018 Blackwell Verlag GmbH.)
Databáze: MEDLINE
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