Polymorphism FSHR (-29G/A) as a genetic agent together with ESRI (XbaIG/A) in women with poor response to controlled ovarian hyperstimulation.

Autor: Zamaniara T; Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran., Taheripanah R; Infertility and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ghaderian SMH; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti of University of Medical Sciences, Tehran, Iran.; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, No 23, Shahid Labbafi Nejad Educational Hospital, Tehran, Iran., Zamaniara E; Department of Midwifery, Faculty of Midwifery, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran., Aghabozorgi SSA; Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti of University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Human antibodies [Hum Antibodies] 2017; Vol. 26 (3), pp. 143-147.
DOI: 10.3233/HAB-180332
Abstrakt: Background: One of the major problems in IVF is the poor response of the ovary to gonadotropins. ESRI and FSHR are two effective genes on controlled ovarian hyperstimulation (COH).
Objectives: Evaluating the correlation of alleles and genotypes of polymorphism (-29G/A) located in the FSH receptor gene and polymorphism (XbaI G/A) located in Estrogen receptor genes with the ovary's response would help to anticipate the results of ovulation in IVF cycles.
Methods: In the present study, two hundred (200) blood samples were taken from infertile women aged 20 to 39 who were under IVF therapy. After DNA extraction from the samples, real-time PCR was performed using a specific probe-primer.
Results: Statistical analysis revealed that the frequency of alleles and genotypes of polymorphisms (-29G/A) and (XbaI A/G) in women with normal to poor response did not have significant correlation.
Databáze: MEDLINE
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