Morphine-potentiated cognitive deficits correlate to suppressed hippocampal iNOS RNA expression and an absent type 1 interferon response in LP-BM5 murine AIDS.

Autor: McLane VD; University of Maine, Graduate School of Biomedical Science and Engineering, Orono, ME 04669, USA; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA. Electronic address: virginia.mclane@vcuhealth.org., Kumar S; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA; North Andover High School, North Andover, MA 01845, USA., Leeming R; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA; University of New England, College of Arts and Sciences, Biological Science Department, Biddeford, ME 04005, USA., Rau S; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA., Willis CL; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA., Cao L; University of New England, College of Osteopathic Medicine, Biddeford, ME 04005, USA. Electronic address: lcao@une.edu.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2018 Jun 15; Vol. 319, pp. 117-129. Date of Electronic Publication: 2018 Mar 06.
DOI: 10.1016/j.jneuroim.2018.02.017
Abstrakt: Opioid use accelerates neurocognitive impairment in HIV/AIDS patients. We assessed the effect of chronic morphine treatment and LP-BM5/murine AIDS (MAIDS) infection on cognition, cytokine production, and type 1 interferon (IFN) expression in the murine CNS. Morphine treatment decreased expression of pro-inflammatory factors (CCL5, iNOS) and reduced cognitive performance in LP-BM5-infected mice, correlating to increased hippocampal viral load and a blunted type 1 IFN response. In the striatum, morphine reduced viral load while increasing IFN-α RNA expression. Our results suggest that differentially regulated type 1 IFN responses may contribute to distinct regional outcomes in the hippocampus and striatum in LP-BM5/MAIDS.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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