A redox strategy to tailor the release properties of Fe(III)-alginate aerogels for oral drug delivery.

Autor: Veres P; Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, Hungary., Sebők D; Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. tér 1, Szeged, Hungary., Dékány I; Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. tér 1, Szeged, Hungary., Gurikov P; Institute for Thermal Separation Process, Hamburg University of Technology (TUHH), Eißendorfer Str. 38, 21073, Hamburg, Germany., Smirnova I; Institute for Thermal Separation Process, Hamburg University of Technology (TUHH), Eißendorfer Str. 38, 21073, Hamburg, Germany., Fábián I; Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, Hungary; MTA-DE Redox and Homogeneous Catalytic Reaction Mechanisms Research Group, Egyetem tér 1, Debrecen, Hungary., Kalmár J; Department of Inorganic and Analytical Chemistry, University of Debrecen, Egyetem tér 1, Debrecen, Hungary. Electronic address: kalmar.jozsef@science.unideb.hu.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2018 May 15; Vol. 188, pp. 159-167. Date of Electronic Publication: 2018 Feb 03.
DOI: 10.1016/j.carbpol.2018.01.098
Abstrakt: Iron(III)-crosslinked alginate aerogel beads (d = 3-5 mm) were prepared and loaded with ibuprofen by using the technique of adsorptive deposition from supercritical CO 2 . Additional formulations were prepared where the aerogels were co-impregnated by ibuprofen and ascorbic acid. The release of ibuprofen from the Fe(III)-alginate is much faster in pH = 7.4 (PBS) than in pH = 2.0 (HCl), which can be explained by the faster dissolution and higher swelling of the alginate matrix in PBS. By decreasing the size of the beads and using a higher G content alginate the release rate could be slightly increased. A marked acceleration of drug release was achieved in both HCl and PBS by incorporating ascorbic acid into the Fe(III)-alginate aerogel preparations. The explanation is that in aqueous media ascorbic acid in situ reduces the crosslinking Fe(III) to Fe(II). The latter does not interact strongly with alginate, which promotes the hydration of the chains, thus the erosion and dissolution of the carrier matrix.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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