Cardiac MR Characterization of left ventricular remodeling in a swine model of infarct followed by reperfusion.
| Autor: | Whitaker J; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.; Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK., Tschabrunn CM; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Jang J; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Leshem E; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., O'Neill M; Division of Imaging Sciences and Biomedical Engineering, King's College, London, UK., Manning WJ; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Anter E; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Nezafat R; Beth Israel Deaconess Medical Center (Cardiovascular Division) and Harvard Medical Schools, Boston, Massachusetts, USA, Department of Medicine (Cardiovascular Division), Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2018 Mar 09. Date of Electronic Publication: 2018 Mar 09. |
| DOI: | 10.1002/jmri.26005 |
| Abstrakt: | Background: Myocardial infarction (MI) survivors are at risk of complications including heart failure and malignant arrhythmias. Purpose: We undertook serial imaging of swine following MI with the aim of characterizing the longitudinal left ventricular (LV) remodeling in a translational model of ischemia-reperfusion-mediated MI. Animal Model: Eight Yorkshire swine underwent mid left anterior descending coronary artery balloon occlusion to create an ischemia-reperfusion experimental model of MI. Field Strength/sequences: 1.5T Philips Achieva scanner. Serial cardiac MRI was performed at 16, 33, and 62 days post-MI, including cine imaging, native and postcontrast T Assessment: Regions of interest were selected on the parametric maps to assess native T Statistical Tests: Parameters estimated at more than two timepoints were compared with a one-way repeated measures analysis of variance. Parametric mapping data were analyzed using a generalized linear mixed model corrected for multiple observations. A result was considered statistically significant at P < 0.05. Results: All animals developed anteroseptal akinesia and hyperenhancement on DB-LGE with a central core of nonenhancing tissue. Mean hyperenhancement volume did not change during the observation period, while the central core contracted from 2.2 ± 1.8 ml at 16 days to 0.08 ± 0.19 ml at 62 days (P = 0.008). Native T Date Conclusion: In this swine model of MI, serial quantitative cardiac MR exams allow characterization of LV remodeling and scar formation. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018. (© 2018 International Society for Magnetic Resonance in Medicine.) |
| Databáze: | MEDLINE |
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