Biomarkers of carcinogenesis and tumour growth in patients with cutaneous melanoma and obstructive sleep apnoea.

Autor:	Santamaria-Martos F; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain., Benítez I; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain., Girón C; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain., Barbé F; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain., Martínez-García MA; Pneumology Dept, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Hernández L; Pneumology Dept, Hospital General de Alicante, Alicante, Spain., Montserrat JM; Pneumology Dept, Hospital Clinic-IDIBAPS, Barcelona, Spain., Nagore E; Dermatology Dept, Instituto Valenciano de Oncologia, Valencia, Spain., Martorell A; Dermatology Dept, Hospital de Manises, Valencia, Spain., Campos-Rodriguez F; Pneumology Dept, Hospital de Valme, Seville, Spain., Corral J; Pneumology Dept, Hospital San Pedro de Alcantara, Cáceres, Spain., Cabriada V; Pneumology Dept, Hospital Cruces, Bilbao, Spain., Abad J; Pneumology Dept, Hospital Germans Trial i Pujol, Barcelona, Spain., Mediano O; Pneumology Dept, Hospital de Guadalajara, Guadalajara, Spain., Troncoso MF; Pneumology Dept, Fundación Jiménez Diaz, Madrid, Spain., Cano-Pumarega I; Pneumology Dept, Hospital de Getafe, Madrid, Spain., Fortuna Gutierrez AM; Pneumology Dept, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain., Diaz-Cambriles T; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Pneumology Dept, Hospital 12 de Octubre, Madrid, Spain., Somoza-Gonzalez M; Pneumology Dept, Hospital Consorcio Terrassa, Barcelona, Spain., Almendros I; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain., Farre R; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.; Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain., Gozal D; Dept of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Sánchez-de-la-Torre M; Group of Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova y Santa Maria, IRB Lleida, Lleida, Spain sanchezdelatorre@gmail.com.; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	The European respiratory journal [Eur Respir J] 2018 Mar 15; Vol. 51 (3). Date of Electronic Publication: 2018 Mar 15 (Print Publication: 2018).
DOI:	10.1183/13993003.01885-2017
Abstrakt:	The goal of this study was to assess the relationship between the severity of obstructive sleep apnoea (OSA) and the levels of carcinogenesis- and tumour growth-related biomarkers in patients with cutaneous melanoma.This multicentre observational study included patients who were newly diagnosed with melanoma. The patients were classified as non-OSA (apnoea-hypopnoea index (AHI) 0-5 events·h -1 ), mild OSA (AHI 5-15 events·h -1 ) and moderate-severe OSA (AHI >15 events·h -1 ). ELISAs were performed to analyse the serum levels of hypoxia- and tumour adhesion-related biomarkers (vascular endothelial growth factor (VEGF), interleukin (IL)-8, intracellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM)-1) and markers of tumour aggressiveness (S100 calcium-binding protein B (S100B) and melanoma inhibitory activity (MIA)). A logistic model adjusted for age, sex and body mass index was fitted to each biomarker, and the AHI served as the dependent variable.360 patients were included (52.2% male, median (interquartile range) age 55.5 (43.8-68.0) years and AHI 8.55 (2.8-19.5) events·h -1 ). The levels of VEGF, IL-8, ICAM-1, S100B and MIA were not related to the severity of OSA. The levels of VCAM-1 were higher in patients with OSA than those without OSA (mild OSA: odds ratio (OR) 2.07, p=0.021; moderate-severe OSA: OR 2.35, p=0.013).In patients with cutaneous melanoma, OSA was associated with elevated circulating levels of VCAM-1 that could indicate the contribution of OSA in tumorigenesis via integrin-based adhesion. Competing Interests: Conflict of interest: None declared. (Copyright ©ERS 2018.)
Databáze:	MEDLINE
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