Otoacoustic emissions in children treated with gentamicin in a secondary hospital.

Autor: Sequi Canet JM; Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España. Electronic address: sequi_jos@gva.es., Angelats Romero CM; Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España., Sequi Sabater JM; Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España., Miralles Torres A; Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España., Boronat Garcia M; Servicio de Laboratorio, Hospital Francesc de Borja, Gandia, Valencia, España., Gomez Delgado M; Servicio de Pediatría, Hospital Francesc de Borja, Gandia, Valencia, España.
Jazyk: English; Spanish; Castilian
Zdroj: Acta otorrinolaringologica espanola [Acta Otorrinolaringol Esp (Engl Ed)] 2018 Sep - Oct; Vol. 69 (5), pp. 291-296. Date of Electronic Publication: 2018 Mar 05.
DOI: 10.1016/j.otorri.2017.09.001
Abstrakt: Introduction: The National Commission for the Early Detection of Hearing Loss (CODEPEH) recommends the re-evaluation of hearing in children who have suffered any potentially harmful event, such as the prescription of ototoxic antibiotics such as gentamicin. The evoked otoacoustic emissions (EOAE) are a good method for assessing the integrity of cochlear functionality.
Material and Method: A prospective study is presented, including 92 children who were treated with intravenous gentamicin for septic risk/sepsis or urinary tract infection. The children underwent serial EOAE: on admission, at the end of treatment and one month later (if altered on discharge).
Results: In the end, none of the subjects were affected by the treatment.
Conclusion: Gentamicin appears to be a safe antibiotic in treatments lasting <10days and at the doses described. EOAE are an inexpensive, fast, non-invasive and reliable method to check for gentamicin ototoxicity. This could save in the determination of drug levels.
(Copyright © 2018 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: