[Dependence of the specific activity of an immunoglobulin against tick-borne encephalitis on the degree of its fragmentation].

Autor: Gavrilenkova VIu, Kargina TM, Shalamberidze TD, Runova VF, Vorob'eva MS
Jazyk: ruština
Zdroj: Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1987 Jan (1), pp. 64-7.
Abstrakt: Immunoglobulin preparations against tick-borne encephalitis with the increasing content of Fab-fragments (from 16% to 45%) have been experimentally obtained. As revealed by testing these samples in vivo for specific activity (in the biological neutralization test), the preparations containing 16% of Fab-fragments show no perceptible decrease of specific activity; its sharp decrease (2-16 times) can be observed in preparations with a high degree of fragmentation (the content of Fab-fragments being equal to 30-45%).
Databáze: MEDLINE