Seropositivity for the human heat shock protein (Hsp)60 accompanying seropositivity for Chlamydia trachomatis is less prevalent among tubal ectopic pregnancy cases than individuals with normal reproductive history.

Autor: Ozyurek ES; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey. Electronic address: sefikeser.ozyurek@saglik.gov.tr., Karacan T; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., Ozdalgicoglu C; Istanbul, Bagcilar Research and Training Hospital, Department of Medical Microbiology, Turkey., Yilmaz S; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., Isik S; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., San M; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., Kaya E; Bagcilar Research and Training Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey.
Jazyk: angličtina
Zdroj: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2018 Apr; Vol. 223, pp. 119-122. Date of Electronic Publication: 2018 Mar 15.
DOI: 10.1016/j.ejogrb.2018.02.022
Abstrakt: Objectives: To investigate the role of anti-human heat shock protein 60 (hHsp60) antibody positivity in the pathogenesis of ectopic pregnancy, following Chlamydia trachomatis (CT) infection.
Study Design: In a case-control study, serological tests for anti-hHsp60 were performed in ectopic pregnancies (study group) and parturients with normal reproductive histories (control group). All participants in both groups were CT IgG(+). hHsp60 IgG(+) prevalences were compared between the two groups, by semiquantitative ELISA. Data were evaluated using nonparametric and parametric tests and multivariable regression.
Results: After an initial pilot study, two groups were formed: 63 ectopic gestations (study group) and 95 normal parturients (control group), all CT IgG(+). Blood samples from all cases were tested for anti-hHsp60 IgG. Age, gravidity, and practising contraception were higher in the control group, while a history of pelvic infections were more common in the study group. Hsp60 IgG(+) was found to be significantly higher in the control group (63/95, 66.3%) compared to study group (30/63, 47.6%). Regression analysis revealed anti-hHsp60 positivity was an independent factor delineating the two groups.
Conclusion: Immunity to hHsp60 is less common in CT IgG(+) ectopic pregnancies than CT IgG(+) fertile subjects without a history of ectopic pregnancies. Hence, our findings suggest that hHsp60 seropositivity may decrease the probability of an ectopic gestation in subjects with previous CT infections.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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