New Crambescidin-Type Alkaloids from the Indonesian Marine Sponge Clathria bulbotoxa.
| Autor: | Kasmiati K; Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. kasmiati74@yahoo.com.; Faculty of Marine Science and Fishery, Hasanuddin University, Jalan Perintis Kemerdekaan KM. 10, Makassar 90245, Indonesia. kasmiati74@yahoo.com., Yoshioka Y; Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan. yyosioka@hiroshima-u.ac.jp., Okamoto T; Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan. tetsuok@hiroshima-u.ac.jp., Ojika M; Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan. ojika@agr.nagoya-u.ac.jp. |
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| Jazyk: | angličtina |
| Zdroj: | Marine drugs [Mar Drugs] 2018 Mar 08; Vol. 16 (3). Date of Electronic Publication: 2018 Mar 08. |
| DOI: | 10.3390/md16030084 |
| Abstrakt: | A crude methanolic extract of the Indonesian sponge Clathria bulbotoxa showed a potent cytotoxic activity against the human epidermoid carcinoma A431 cells. An investigation of the active components led to the isolation of three new compounds named crambescidins 345 ( 1 ), 361 ( 2 ), and 373 ( 3 ), together with the known related metabolites crambescidins 359 ( 4 ), 657 ( 5 ), and 800 ( 6 ). The structures of the compounds were determined by spectroscopic analysis. These compounds 1 - 4 that possess a simple pentacyclic guanidine core exhibited moderate cytotoxicity against the A431 cells with the IC Competing Interests: The authors declare no conflict of interest. |
| Databáze: | MEDLINE |
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