CD8+ T cells in beige adipogenesis and energy homeostasis.

Autor:	Moysidou M; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.; University of Crete, School of Medicine, Heraklion, Crete, Greece., Karaliota S; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Kodela E; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.; University of Crete, School of Medicine, Heraklion, Crete, Greece., Salagianni M; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Koutmani Y; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Katsouda A; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Kodella K; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Tsakanikas P; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Ourailidou S; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Andreakos E; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Kostomitsopoulos N; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece., Skokos D; Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA., Chatzigeorgiou A; Technische Universität Dresden, School of Medicine, Dresden, Germany., Chung KJ; Technische Universität Dresden, School of Medicine, Dresden, Germany., Bornstein S; Technische Universität Dresden, School of Medicine, Dresden, Germany., Sleeman MW; Department of Physiology, Monash University, Clayton, Victoria, Australia., Chavakis T; Technische Universität Dresden, School of Medicine, Dresden, Germany., Karalis KP; Clinical, Experimental Surgery & Translational Research, Biomedical Research Foundation Academy of Athens, Athens, Greece.; Technische Universität Dresden, School of Medicine, Dresden, Germany.; Endocrine Division, Boston Children's Hospital, Boston, Massachusetts, USA.
Jazyk:	angličtina
Zdroj:	JCI insight [JCI Insight] 2018 Mar 08; Vol. 3 (5). Date of Electronic Publication: 2018 Mar 08.
DOI:	10.1172/jci.insight.95456
Abstrakt:	Although accumulation of lymphocytes in the white adipose tissue (WAT) in obesity is linked to insulin resistance, it remains unclear whether lymphocytes also participate in the regulation of energy homeostasis in the WAT. Here, we demonstrate enhanced energy dissipation in Rag1-/- mice, increased catecholaminergic input to subcutaneous WAT, and significant beige adipogenesis. Adoptive transfer experiments demonstrated that CD8+ T cell deficiency accounts for the enhanced beige adipogenesis in Rag1-/- mice. Consistently, we identified that CD8-/- mice also presented with enhanced beige adipogenesis. The inhibitory effect of CD8+ T cells on beige adipogenesis was reversed by blockade of IFN-γ. All together, our findings identify an effect of CD8+ T cells in regulating energy dissipation in lean WAT, mediated by IFN-γ modulation of the abundance of resident immune cells and of local catecholaminergic activity. Our results provide a plausible explanation for the clinical signs of metabolic dysfunction in diseases characterized by altered CD8+ T cell abundance and suggest targeting of CD8+ T cells as a promising therapeutic approach for obesity and other diseases with altered energy homeostasis.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu