Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats.

Autor:	Andrade PHM; Fellow PhD degree, Postgraduate Program in Health and Development of the Central West Region, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. Acquisition, analysis and interpretation of data; manuscript writing., Portugal LC; PhD, Department of Morphophysiology, UFMS, Campo Grande-MS, Brazil. Histopathological examinations, manuscript preparation, critical revision., Rondon ES; PhD, Department of Veterinary Medicine, UFMS, Campo Grande-MS, Brazil. Acquisition, analysis and interpretation of data; manuscript preparation; critical revision., Kadri MCT; PhD, Center for Biological and Health Sciences (CCBS), UFMS, Campo Grande-MS, Brazil. Manuscript preparation, critical revision., Matos MFC; PhD, Faculty of Pharmaceutical Sciences, Food and Nutrition, UFMS, Campo Grande-MS, Brazil. Acquisition, analysis and interpretation of data; manuscript preparation, critical revision.
Jazyk:	angličtina
Zdroj:	Acta cirurgica brasileira [Acta Cir Bras] 2018 Feb; Vol. 33 (2), pp. 185-196.
DOI:	10.1590/s0102-865020180020000010
Abstrakt:	Purpose: To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential. Methods: Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups: Control group (GC.diab), no therapeutic intervention on the wound; Vehicle's Control group, topical via, in diabetic rats (GCvt.diab): Powder Shell Group (PC) applied topically (GPCvt.diab): Experimental group was administered topically shortly after wound dressing and once a day during the experimental period (3, 7, 14 and 21 days) the composition containing the powdered shell of the snail. The following variables related to the healing potential were analyzed: macroscopic one, where the capacity of reduction of the wound area was evaluated; histological analysis in HE, angiogenic activity, morphometric analysis (re-epithelization), leukocyte inflammatory infiltrate; leukocyte count and also differentiation in peripheral blood. Results: The topical application in wounds of diabetic rats presented healing activity, accelerating wound closure, stimulating angiogenesis and being pro-inflammatory in the early and anti-inflammatory stages in the final times of the healing process. Conclusion: The topical administration of the powdered shell on wounds of diabetic patients becomes a therapeutic option of low cost, with ease in the administration and access as well.
Databáze:	MEDLINE
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