| Autor: |
Yagudin TA, Klyatchko EV, Zatsepin SS, Morozkina EV, Benevolensky SV, Shemchukova OB, Pozdnyakova LP, Solopova ON, Sveshnikov PG |
| Jazyk: |
ruština |
| Zdroj: |
Prikladnaia biokhimiia i mikrobiologiia [Prikl Biokhim Mikrobiol] 2016 Jul-Aug; Vol. 52 (4), pp. 370-6. |
| Abstrakt: |
The yeast strain Pichia pastoris, a producer of humanized F(ab’)2 fragments of rabies-blocking antibodies, has been obtained. Human chaperone BiP coexpression caused a twofold increase of the immunoglobulins secretion level. The use of Fos and Jun zippers in the composition of heavy chains facilitated the dimerization of F(ab’)2 fragments of the shared pool of secreted immunoglobulins up to 75%. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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