An impact of Deoxynivalenol produced by Fusarium graminearum on broiler chickens.

Autor: Yu YH; Department of Biotechnology and Animal Science, National Ilan University, I-Lan, Taiwan., Hsiao FS; Department of Animal Science and Biotechnology, Tunghai University, Taichung, Taiwan., Proskura WS; Laboratory of Molecular Cytogenetics, West Pomeranian University of Technology, Szczecin, Poland., Dybus A; Laboratory of Molecular Cytogenetics, West Pomeranian University of Technology, Szczecin, Poland., Siao YH; Department of Biotechnology and Animal Science, National Ilan University, I-Lan, Taiwan., Cheng YH; Department of Biotechnology and Animal Science, National Ilan University, I-Lan, Taiwan.
Jazyk: angličtina
Zdroj: Journal of animal physiology and animal nutrition [J Anim Physiol Anim Nutr (Berl)] 2018 Aug; Vol. 102 (4), pp. 1012-1019. Date of Electronic Publication: 2018 Mar 07.
DOI: 10.1111/jpn.12883
Abstrakt: Deoxynivalenol (DON) is a major mycotoxin from the trichothecene family of mycotoxins produced by Fusarium fungi that cause disease in grains. Food and feed contaminated with DON cause a variety of adverse health effects in humans and farm animals. However, the fermentation conditions of DON for toxicological study remain to be optimised. Deoxynivalenol levels were increased in a constant temperature of 20°C after fermentation for 7 and 14 days compared with cycling temperatures between 10-20°C and 15-20°C. We have established that optimum conditions for DON production on rice-based medium is constant temperature at 20°C. In feeding experiments, the villus height and the ratio of villus height and crypt depth were reduced in the duodenum of DON-fed broiler chickens, whereas a mycotoxin degradation agent efficiently reversed the abnormal morphology of the small intestine in the DON-fed broilers. The expression of pro-inflammatory gene, COX-2, was induced in the spleen and bursa of Fabricius of DON-fed broilers. This effect was alleviated in the presence of mycotoxin degradation agent. DON produced in solid-state fermentation is able to cause toxic effects in broilers and induce an abnormal morphology of the small intestine, particularly the duodenum.
(© 2018 Blackwell Verlag GmbH.)
Databáze: MEDLINE
Externí odkaz: