| Autor: |
Van der Berg JP; Molecular Microbiology , Groningen Biomolecular Sciences and Biotechnology Institute , University of Groningen , Nijenborgh 7, 9747 AG , Groningen , The Netherlands . Email: a.j.m.driessen@rug.nl., Velema WA; Center for Systems Chemistry , Stratingh Institute for Chemistry , University of Groningen , Nijenborgh 4, 9747 AG , Groningen , The Netherlands . Email: b.l.feringa@rug.nl., Szymanski W; Center for Systems Chemistry , Stratingh Institute for Chemistry , University of Groningen , Nijenborgh 4, 9747 AG , Groningen , The Netherlands . Email: b.l.feringa@rug.nl.; Department of Radiology , University of Groningen , University Medical Centre Groningen , Groningen , The Netherlands., Driessen AJM; Molecular Microbiology , Groningen Biomolecular Sciences and Biotechnology Institute , University of Groningen , Nijenborgh 7, 9747 AG , Groningen , The Netherlands . Email: a.j.m.driessen@rug.nl., Feringa BL; Center for Systems Chemistry , Stratingh Institute for Chemistry , University of Groningen , Nijenborgh 4, 9747 AG , Groningen , The Netherlands . Email: b.l.feringa@rug.nl. |
| Abstrakt: |
Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa . |
