What about sentinel lymph node biopsy for early breast cancer during pregnancy?

Autor: Balaya V; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Human Anatomy Institute EA 4465 UFR Biomédicale des Saints-Pères, 45, rue des Saints-Pères, 75006 Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France. Electronic address: vbalaya@hotmail.com., Bonsang-Kitzis H; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Ngo C; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Delomenie M; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Gosset M; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Mimouni M; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Nos C; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France., David PM; Nuclear Medecine Department, European Georges Pompidou Hospital, 20 rue Leblanc, 75908 Paris Cedex 15, France., Bats AS; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France., Lecuru F; Gynecologic and Breast Oncologic Surgery, Department, European Georges Pompidou Hospital, 20, rue Leblanc, 75908 Paris Cedex 15, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.
Jazyk: angličtina
Zdroj: Journal of gynecology obstetrics and human reproduction [J Gynecol Obstet Hum Reprod] 2018 May; Vol. 47 (5), pp. 205-207. Date of Electronic Publication: 2018 Mar 03.
DOI: 10.1016/j.jogoh.2018.03.003
Abstrakt: Pregnancy-associated breast cancer is rare, but this clinical situation arises in 1/10,000-1/3000 pregnancies. In patients presenting an early-stage breast tumor devoid of clinically pathological lymph node, sentinel lymph node (SLN) biopsy has not yet been validated as a routine procedure for pregnant women due to the lack of data in the literature. The blue dye injection is not recommended because of 2% theoretical risk of anaphylactic shock. Several studies have shown that Tc 99m injection at conventional dose between 12.1 and 18.5MBq exposed the fetus to an irradiation between 0.011 and 0.0245mSv much below the 50mSv recommended threshold. As evidenced by lymphoscintigraphy scans, the dose of injected Tc 99m is localized at the injection site and in the SLN. According to the literature, the SLN technique does not seem to impact the fetal or obstetrical prognosis. Studies involving larger cohorts are required to confirm these data and to indicate this technique in pregnant women. Considering the benefit for the patient and the low risk incurred on both fetal and obstetrical levels, it appears reasonable to discuss the indication of SLN on a case-by-case basis in multidisciplinary oncologic meetings.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: