| Autor: |
Chen HP; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Zhao ZZ; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China.; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China., Li ZH; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Huang Y; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Zhang SB; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Tang Y; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China.; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China., Yao JN; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China.; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China., Chen L; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Isaka M; National Center for Genetic Engineering and Biotechnology (BIOTEC) , 113 Thailand Science Park, Phaholyothin Road , Klong Luang , Pathumthani 12120 , Thailand., Feng T; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China., Liu JK; College of Pharmaceutical Sciences , South-CentralUniversity for Nationalities , Wuhan 430074 , China. |
| Abstrakt: |
This study features the isolation and identification of 12 lanostane-type triterpenoids, namely lepiotaprocerins A-L, 1-12, from the fruiting bodies of the Poland-collected edible mushroom Macrolepiota procera. The structures and the absolute configurations of the new compounds were ambiguously established by extensive spectroscopic analyses, ECD calculation, and single-crystal X-ray diffraction analyses. Structurally, lepiotaprocerins A-F, 1-6, are distinguished by the presence of a rare "1-en-1,11-epoxy" moiety which has not been previously described in the lanostane class. Biologically, lepiotaprocerins A-F, 1-6, displayed more significant inhibitions of nitric oxide (NO) production than the positive control L- N G -monomethyl arginine (L-NMMA) (IC 50 47.1 μM), and lepiotaprocerins G-L, 7-12, showed various cytotoxicity potencies against a panel of human cancer cell lines. Compound 9 also displayed antitubercular activity against Mycobacterium tuberculosis H37Ra with a minimal inhibitory concentration (MIC) 50 μg/mL. |
