Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior.

Autor: Deroche-Gamonet V; Neurocentre Magendie, Physiopathology of addiction and traumatic memories group, INSERM U1215, 33077, Bordeaux, France.; Université de Bordeaux, 33077, Bordeaux, France., Revest JM; Neurocentre Magendie, Physiopathology of addiction and traumatic memories group, INSERM U1215, 33077, Bordeaux, France.; Université de Bordeaux, 33077, Bordeaux, France., Fiancette JF; Neurocentre Magendie, Physiopathology of addiction and traumatic memories group, INSERM U1215, 33077, Bordeaux, France.; Université de Bordeaux, 33077, Bordeaux, France., Balado E; Neurocentre Magendie, Physiopathology of addiction and traumatic memories group, INSERM U1215, 33077, Bordeaux, France.; Université de Bordeaux, 33077, Bordeaux, France., Koehl M; Université de Bordeaux, 33077, Bordeaux, France.; Neurocentre Magendie, Neurogenesis and physiopathology group, INSERM U1215, 33077, Bordeaux, France., Grosjean N; Université de Bordeaux, 33077, Bordeaux, France.; Neurocentre Magendie, Neurogenesis and physiopathology group, INSERM U1215, 33077, Bordeaux, France., Abrous DN; Université de Bordeaux, 33077, Bordeaux, France. nora.abrous@inserm.fr.; Neurocentre Magendie, Neurogenesis and physiopathology group, INSERM U1215, 33077, Bordeaux, France. nora.abrous@inserm.fr., Piazza PV; Neurocentre Magendie, Physiopathology of addiction and traumatic memories group, INSERM U1215, 33077, Bordeaux, France.; Université de Bordeaux, 33077, Bordeaux, France.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2019 Feb; Vol. 24 (2), pp. 312-320. Date of Electronic Publication: 2018 Mar 05.
DOI: 10.1038/s41380-018-0038-0
Abstrakt: The hippocampus is the main locus for adult dentate gyrus (DG) neurogenesis. A number of studies have shown that aberrant DG neurogenesis correlates with many neuropsychiatric disorders, including drug addiction. Although clear causal relationships have been established between DG neurogenesis and memory dysfunction or mood-related disorders, evidence of the causal role of DG neurogenesis in drug-seeking behaviors has not been established. Here we assessed the role of new DG neurons in cocaine self-administration using an inducible transgenic approach that selectively depletes adult DG neurogenesis. Our results show that transgenic mice with decreased adult DG neurogenesis exhibit increased motivation to self-administer cocaine and a higher seeking response to cocaine-related cues. These results identify adult hippocampal neurogenesis as a key factor in vulnerability to cocaine addiction.
Databáze: MEDLINE
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