Reversal by indomethacin of renal effects of dopamine in subjects with normal renal function.

Autor: Yeyati NL, Altenberg GA, Rainoldi FA, Greco J
Jazyk: angličtina
Zdroj: Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia [Acta Physiol Pharmacol Latinoam] 1986; Vol. 36 (2), pp. 127-33.
Abstrakt: In five subjects with normal renal function, intravenous dopamine, at a rate of 6 ug/kg/min, produces a renal vasodilation, increase in Na excretion and reduction in urinary osmolality, without modification in glomerular filtration rate. These effects were reversed by intravenous indomethacin (2 mg/kg), suggesting that the renal effects of dopamine might depend on normal prostaglandins production.
Databáze: MEDLINE