Macrophage-derived GPNMB accelerates skin healing.

Autor: Silva WN; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Prazeres PHDM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Paiva AE; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Lousado L; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Turquetti AOM; Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., Barreto RSN; Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., de Alvarenga EC; Department of Natural Sciences, Federal University of São João del Rei, São João Del Rey, Brazil., Miglino MA; Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil., Gonçalves R; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil., Mintz A; Department of Radiology, Columbia University Medical Center, New York, NY, USA., Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Brazil.; Anatomy of Domestic and Wild Animals Program, Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.; Department of Radiology, Columbia University Medical Center, New York, NY, USA.
Jazyk: angličtina
Zdroj: Experimental dermatology [Exp Dermatol] 2018 Jun; Vol. 27 (6), pp. 630-635. Date of Electronic Publication: 2018 Apr 30.
DOI: 10.1111/exd.13524
Abstrakt: Healing is a vital response important for the re-establishment of the skin integrity following injury. Delayed or aberrant dermal wound healing leads to morbidity in patients. The development of therapies to improve dermal healing would be useful. Currently, the design of efficient treatments is stalled by the lack of detailed knowledge about the cellular and molecular mechanisms involved in wound healing. Recently, using state-of-the-art technologies, it was revealed that macrophages signal via GPNMB to mesenchymal stem cells, accelerating skin healing. Strikingly, transplantation of macrophages expressing GPNMB improves skin healing in GPNMB-mutant mice. Additionally, topical treatment with recombinant GPNMB restored mesenchymal stem cells recruitment and accelerated wound closure in the diabetic skin. From a drug development perspective, this GPNMB is a new candidate for skin healing.
(© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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