Liquid chromatography-tandem MS/MS method for simultaneous quantification of paracetamol, chlorzoxazone and aceclofenac in human plasma: An application to a clinical pharmacokinetic study.
Autor: | Mohamed D; Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.; Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, October University for Modern Sciences and Arts, 6 October City, Egypt., Hegazy MA; Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Elshahed MS; Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt., Toubar SS; Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt., Helmy MI; Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt. |
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Jazyk: | angličtina |
Zdroj: | Biomedical chromatography : BMC [Biomed Chromatogr] 2018 Jul; Vol. 32 (7), pp. e4232. Date of Electronic Publication: 2018 Apr 19. |
DOI: | 10.1002/bmc.4232 |
Abstrakt: | A facile, fast and specific method based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous quantitation of paracetamol, chlorzoxazone and aceclofenac in human plasma was developed and validated. Sample preparation was achieved by liquid-liquid extraction. The analysis was performed on a reversed-phase C (Copyright © 2018 John Wiley & Sons, Ltd.) |
Databáze: | MEDLINE |
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